Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cel...
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| Veröffentlicht in: | Nature Medicine 2007-01, Vol.13 (1), p.35-37 |
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| creator | Desreumaux, Pierre Rousseaux, Christel Thuru, Xavier Gelot, Agathe Barnich, Nicolas Neut, Christel Dubuquoy, Laurent Dubuquoy, Caroline Merour, Emilie Geboes, Karen Chamaillard, Mathias Ouwehand, Arthur Leyer, Greg Carcano, Didier Colombel, Jean-Frédéric Ardid, Denis |
| description | Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treament of abdominal pain and irritable bowel syndrome. |
| doi_str_mv | 10.1038/nm1521 |
| format | Article |
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We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treament of abdominal pain and irritable bowel syndrome.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>EISSN: 1744-7933</identifier><identifier>DOI: 10.1038/nm1521</identifier><identifier>PMID: 17159985</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject><![CDATA[Abdominal Pain - physiopathology ; Abdominal Pain - prevention & control ; Administration, Oral ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - pharmacology ; Animals ; Bacteria ; Biomedical and Life Sciences ; Biomedicine ; brief-communication ; Cancer Research ; Cannabinoid Receptor Antagonists ; Colon - drug effects ; Colon - microbiology ; Colon - physiopathology ; Dose-Response Relationship, Drug ; Gastrointestinal diseases ; HT29 Cells ; Humans ; Hypersensitivity ; Indoles - administration & dosage ; Indoles - pharmacology ; Infectious Diseases ; Intestines - drug effects ; Intestines - microbiology ; Intestines - physiopathology ; Irritable bowel syndrome ; Lactobacillus acidophilus ; Lactobacillus acidophilus - physiology ; Life Sciences ; Male ; Metabolic Diseases ; Mice ; Mice, Inbred BALB C ; Microbiology ; Molecular Medicine ; Morphine - administration & dosage ; Morphine - pharmacology ; Naloxone - administration & dosage ; Naloxone - pharmacology ; Narcotic Antagonists - administration & dosage ; Narcotic Antagonists - pharmacology ; Neurosciences ; Pain ; Probiotics - administration & dosage ; Probiotics - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB2 - antagonists & inhibitors ; Receptor, Cannabinoid, CB2 - biosynthesis ; Receptor, Cannabinoid, CB2 - physiology ; Receptors, Cannabinoid - biosynthesis ; Receptors, Cannabinoid - physiology ; Receptors, Opioid - biosynthesis ; Receptors, Opioid - physiology ; Receptors, Opioid, mu - antagonists & inhibitors ; Receptors, Opioid, mu - biosynthesis ; Receptors, Opioid, mu - physiology ; Rectum - drug effects ; Rectum - microbiology ; Rectum - physiopathology]]></subject><ispartof>Nature Medicine, 2007-01, Vol.13 (1), p.35-37</ispartof><rights>Springer Nature America, Inc. 2006</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2007</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c695t-dbf0fad3c6a03bd8fcad6c2d89e7a7da5feda02e12e258e196fba397c13e6c9c3</citedby><cites>FETCH-LOGICAL-c695t-dbf0fad3c6a03bd8fcad6c2d89e7a7da5feda02e12e258e196fba397c13e6c9c3</cites><orcidid>0000-0001-9465-7844 ; 0000-0003-3596-5497 ; 0000-0003-4320-7338 ; 0000-0002-0998-4160</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm1521$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm1521$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17159985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02667010$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Desreumaux, Pierre</creatorcontrib><creatorcontrib>Rousseaux, Christel</creatorcontrib><creatorcontrib>Thuru, Xavier</creatorcontrib><creatorcontrib>Gelot, Agathe</creatorcontrib><creatorcontrib>Barnich, Nicolas</creatorcontrib><creatorcontrib>Neut, Christel</creatorcontrib><creatorcontrib>Dubuquoy, Laurent</creatorcontrib><creatorcontrib>Dubuquoy, Caroline</creatorcontrib><creatorcontrib>Merour, Emilie</creatorcontrib><creatorcontrib>Geboes, Karen</creatorcontrib><creatorcontrib>Chamaillard, Mathias</creatorcontrib><creatorcontrib>Ouwehand, Arthur</creatorcontrib><creatorcontrib>Leyer, Greg</creatorcontrib><creatorcontrib>Carcano, Didier</creatorcontrib><creatorcontrib>Colombel, Jean-Frédéric</creatorcontrib><creatorcontrib>Ardid, Denis</creatorcontrib><title>Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors</title><title>Nature Medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. 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physiopathology</topic><topic>Abdominal Pain - prevention & control</topic><topic>Administration, Oral</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>brief-communication</topic><topic>Cancer Research</topic><topic>Cannabinoid Receptor Antagonists</topic><topic>Colon - drug effects</topic><topic>Colon - microbiology</topic><topic>Colon - physiopathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gastrointestinal diseases</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Indoles - administration & dosage</topic><topic>Indoles - pharmacology</topic><topic>Infectious Diseases</topic><topic>Intestines - drug effects</topic><topic>Intestines - microbiology</topic><topic>Intestines - physiopathology</topic><topic>Irritable bowel syndrome</topic><topic>Lactobacillus acidophilus</topic><topic>Lactobacillus acidophilus - 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| identifier | ISSN: 1078-8956 |
| ispartof | Nature Medicine, 2007-01, Vol.13 (1), p.35-37 |
| issn | 1078-8956 1546-170X 1744-7933 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02667010v1 |
| source | MEDLINE; Nature; SpringerNature Journals; EZB Electronic Journals Library |
| subjects | Abdominal Pain - physiopathology Abdominal Pain - prevention & control Administration, Oral Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Bacteria Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Cannabinoid Receptor Antagonists Colon - drug effects Colon - microbiology Colon - physiopathology Dose-Response Relationship, Drug Gastrointestinal diseases HT29 Cells Humans Hypersensitivity Indoles - administration & dosage Indoles - pharmacology Infectious Diseases Intestines - drug effects Intestines - microbiology Intestines - physiopathology Irritable bowel syndrome Lactobacillus acidophilus Lactobacillus acidophilus - physiology Life Sciences Male Metabolic Diseases Mice Mice, Inbred BALB C Microbiology Molecular Medicine Morphine - administration & dosage Morphine - pharmacology Naloxone - administration & dosage Naloxone - pharmacology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology Neurosciences Pain Probiotics - administration & dosage Probiotics - pharmacology Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - biosynthesis Receptor, Cannabinoid, CB2 - physiology Receptors, Cannabinoid - biosynthesis Receptors, Cannabinoid - physiology Receptors, Opioid - biosynthesis Receptors, Opioid - physiology Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - biosynthesis Receptors, Opioid, mu - physiology Rectum - drug effects Rectum - microbiology Rectum - physiopathology |
| title | Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T19%3A07%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lactobacillus%20acidophilus%20modulates%20intestinal%20pain%20and%20induces%20opioid%20and%20cannabinoid%20receptors&rft.jtitle=Nature%20Medicine&rft.au=Desreumaux,%20Pierre&rft.date=2007-01-01&rft.volume=13&rft.issue=1&rft.spage=35&rft.epage=37&rft.pages=35-37&rft.issn=1078-8956&rft.eissn=1546-170X&rft_id=info:doi/10.1038/nm1521&rft_dat=%3Cgale_hal_p%3EA192446613%3C/gale_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223116210&rft_id=info:pmid/17159985&rft_galeid=A192446613&rfr_iscdi=true |