Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol

To characterize the possible cytotoxic effects of oxysterols (7beta-hydroxycholesterol (7beta-OH), 25-hydroxycholesterol (25-OH)) in human retinal pigment epithelial cells (ARPE-19) and to detail the relationships between some of these effects. ARPE-19 cells were treated with 7beta-OH and 25-OH. Cel...

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Veröffentlicht in:	Current eye research 2008-09, Vol.33 (9), p.769-781
Hauptverfasser:	Malvitte, Laure, Montange, Thomas, Vejux, Anne, Joffre, Corinne, Bron, Alain, Creuzot-Garcher, Catherine, Lizard, Gerard
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Inducing Factor - metabolism Blotting, Western Caspase 3 - metabolism Cell Death - drug effects Cell Membrane Permeability - physiology Cell Survival - drug effects Cells, Cultured Cysteine Proteinase Inhibitors - pharmacology Cytochromes c - metabolism Dipeptides - pharmacology DNA Fragmentation Electrophoresis, Agar Gel Enzyme Activation Flow Cytometry Fluorescent Antibody Technique, Indirect Food and Nutrition Human health and pathology Humans Hydroxycholesterols - pharmacology Ketones - pharmacology Life Sciences Lysosomes - metabolism Membrane Potentials - physiology Mitochondrial Membranes - physiology Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - pathology Sensory Organs
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