A vaccine based on exosomes secreted by a dendritic cell line confers protection against T. gondii infection in syngeneic and allogeneic mice

Our results show that exosomes secreted by SRDC pulsed in vitro with Toxoplasma gondii-derived antigens (Exo-TAg) induced protective responses against infection with the parasite in both syngeneic and allogeneic mice. After oral infection, syngeneic CBA/J mice exhibited significantly fewer cysts in...

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Veröffentlicht in:	Microbes and infection 2007-11, Vol.9 (14), p.1614-1622
Hauptverfasser:	Beauvillain, Céline, Ruiz, Sophie, Guiton, Rachel, Bout, Daniel, Dimier-Poisson, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antibodies, Protozoan - blood Antigens, Protozoan - immunology Applied microbiology Biological and medical sciences Cell Line Cytoplasmic Vesicles - secretion Dendritic cells Dendritic Cells - immunology Dendritic Cells - transplantation Dendritic Cells - ultrastructure Exocytosis Exosomes Female Fundamental and applied biological sciences. Psychology Life Sciences Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Inbred CBA Microbiology Protozoan Vaccines - administration & dosage Protozoan Vaccines - immunology Toxoplasma Toxoplasma - immunology Toxoplasma - pathogenicity Toxoplasma gondii Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - prevention & control Transplantation, Homologous Transplantation, Isogeneic Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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