Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro

Bone sialoprotein (BSP) and osteopontin (OPN) belong to the small integrin‐binding ligand N‐linked glycoprotein (SIBLING) family, whose members interact with bone cells and bone mineral. Previously, we showed that BSP knockout (BSP−/−) mice have a higher bone mass than wild type (BSP+/+) littermates...

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Veröffentlicht in:	Journal of bone and mineral research 2010-12, Vol.25 (12), p.2669-2679
Hauptverfasser:	Boudiffa, Maya, Wade‐Gueye, Ndéye Marième, Guignandon, Alain, Vanden‐Bossche, Arnaud, Sabido, Odile, Aubin, Jane E, Jurdic, Pierre, Vico, Laurence, Lafage‐Proust, Marie Hélène, Malaval, Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Biomarkers - metabolism Bone Resorption - metabolism BSP Cell Count Cell Differentiation - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Computer Science Dentin - metabolism Durapatite - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Profiling Humans Integrin-Binding Sialoprotein - deficiency Integrin-Binding Sialoprotein - genetics Integrin-Binding Sialoprotein - metabolism Life Sciences Mice Minerals - metabolism Oligopeptides - pharmacology OSTEOCLAST Osteoclasts - drug effects Osteoclasts - metabolism Osteoclasts - pathology Osteogenesis - drug effects Osteopontin - genetics Osteopontin - metabolism Recombinant Proteins - pharmacology RESORPTION SIBLING Skeleton and joints Spleen - cytology Vertebrates: osteoarticular system, musculoskeletal system
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