Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway

Protease-activated receptor-2 (PAR(2)), a receptor highly expressed in the respiratory tract, can influence inflammation at mucosal surfaces. Although the effects of PAR(2) in the innate immune response to bacterial infection have been documented, knowledge of its role in the context of viral infect...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-06, Vol.182 (12), p.7795-7802
Hauptverfasser:	Khoufache, Khaled, LeBouder, Fanny, Morello, Eric, Laurent, Fabrice, Riffault, Sabine, Andrade-Gordon, Patricia, Boullier, Severine, Rousset, Perrine, Vergnolle, Nathalie, Riteau, Béatrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Dogs Female Gene Expression Regulation Humans Immunology Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - pathogenicity Interferon-gamma - immunology Interferon-gamma - metabolism Interferon-gamma - secretion Life Sciences Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Receptor, PAR-2 - agonists Receptor, PAR-2 - deficiency Receptor, PAR-2 - genetics Receptor, PAR-2 - metabolism Signal Transduction Survival Rate Up-Regulation
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