17 beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha

Aim of the present study was to investigate whether estrogens were able to directly activate rapid signaling pathways controlling spermatogenesis in rat pachytene spermatocytes (PS). Classically, estrogens act by binding to estrogen receptors (ERs) alpha and beta. Recently, it has been demonstrated...

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Veröffentlicht in:	Molecular and cellular endocrinology 2010-05, Vol.320 (1-2), p.136-144
Hauptverfasser:	Chimento, Adele, Sirianni, Rosa, Delalande, Christelle, Silandre, Dorothèe, Bois, Camille, Andò, Sebastiano, Maggiolini, Marcello, Carreau, Serge, Pezzi, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Apoptosis Apoptosis - drug effects Cells, Cultured Cellular Computer Science Enzyme Activation - drug effects Estradiol - pharmacology Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Estrogens Inhibitors Life Sciences Male Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Pachytene Stage - drug effects Pathways Phenols - pharmacology Polystyrene resins Proto-Oncogene Proteins c-jun - metabolism Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Receptors Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Spermatocytes - cytology Spermatocytes - drug effects Spermatocytes - enzymology Spermatocytes - metabolism
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