Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations
Magnesium deficiency may be induced by a diet impoverished in magnesium. This nutritional deficit promotes chronic inflammatory and oxidative stresses, hyperexcitability and, in mice, susceptibility to audiogenic seizures. Potentiation by low-magnesium concentrations of the opening of N-methyl-d-asp...
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| Veröffentlicht in: | British journal of nutrition 2009-02, Vol.101 (3), p.317-321 |
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| creator | Maurois, Pierre Pages, Nicole Bac, Pierre German-Fattal, Michèle Agnani, Geneviève Delplanque, Bernadette Durlach, Jean Poupaert, Jacques Vamecq, Joseph |
| description | Magnesium deficiency may be induced by a diet impoverished in magnesium. This nutritional deficit promotes chronic inflammatory and oxidative stresses, hyperexcitability and, in mice, susceptibility to audiogenic seizures. Potentiation by low-magnesium concentrations of the opening of N-methyl-d-aspartate (NMDA) receptor/calcium channel in in vitro and ex vivo studies, and responsiveness to magnesium of in vivo brain injury states are now well established. By contrast, little or no specific attention has been, however, paid to the in vivo NMDA receptor function/excitability in magnesium deficiency. The present work reports for the first time that, in mice undergoing chronic nutritional deprivation in magnesium (35 v. 930 parts per million for 27 d in OF1 mice), NMDA-induced seizure threshold is significantly decreased (38 % of normal values). The attenuation in the drop of NMDA seizure threshold (percentage of reversal) was 58 and 20 % upon acute intraperitoneal administrations of magnesium chloride hexahydrate (28 mg magnesium/kg) and the antioxidant ebselen (20 mg/kg), respectively. In nutritionally magnesium-deprived animals, audiogenic seizures are completely prevented by these compound doses. Taken as a whole, our data emphasise that chronic magnesium deprivation in mice is a nutritional in vivo model for a lowered NMDA receptor activation threshold. This nutritional model responds remarkably to acute magnesium supply and moderately to acute antioxidant administration. |
| doi_str_mv | 10.1017/S0007114508006752 |
| format | Article |
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This nutritional deficit promotes chronic inflammatory and oxidative stresses, hyperexcitability and, in mice, susceptibility to audiogenic seizures. Potentiation by low-magnesium concentrations of the opening of N-methyl-d-aspartate (NMDA) receptor/calcium channel in in vitro and ex vivo studies, and responsiveness to magnesium of in vivo brain injury states are now well established. By contrast, little or no specific attention has been, however, paid to the in vivo NMDA receptor function/excitability in magnesium deficiency. The present work reports for the first time that, in mice undergoing chronic nutritional deprivation in magnesium (35 v. 930 parts per million for 27 d in OF1 mice), NMDA-induced seizure threshold is significantly decreased (38 % of normal values). The attenuation in the drop of NMDA seizure threshold (percentage of reversal) was 58 and 20 % upon acute intraperitoneal administrations of magnesium chloride hexahydrate (28 mg magnesium/kg) and the antioxidant ebselen (20 mg/kg), respectively. In nutritionally magnesium-deprived animals, audiogenic seizures are completely prevented by these compound doses. Taken as a whole, our data emphasise that chronic magnesium deprivation in mice is a nutritional in vivo model for a lowered NMDA receptor activation threshold. This nutritional model responds remarkably to acute magnesium supply and moderately to acute antioxidant administration.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114508006752</identifier><identifier>PMID: 21129231</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acoustic Stimulation - adverse effects ; acute magnesium chloride hexahydrate ; animal models ; Animals ; Antioxidants ; Antioxidants - administration & dosage ; Antioxidants - pharmacology ; Audiogenic seizures ; Azoles - administration & dosage ; Azoles - pharmacology ; Biological and medical sciences ; Calcium channels ; chronic diseases ; Convulsions & seizures ; Diet ; dietary mineral supplements ; dietary minerals ; dietary supplements ; Dose-Response Relationship, Drug ; Ebselen ; Feeding. Feeding behavior ; Food and Nutrition ; Fundamental and applied biological sciences. Psychology ; human diseases ; human nutrition ; Life Sciences ; Magnesium ; Magnesium - administration & dosage ; Magnesium - pharmacology ; magnesium chloride ; Magnesium chloride hexahydrate ; Magnesium Deficiency - complications ; Magnesium Deficiency - drug therapy ; Mice ; N-methyl-D-aspartate receptor ; N-methyl-D-aspartate-induced seizure ; N-Methylaspartate - toxicity ; nutrient deficiencies ; Nutrition ; Nutritional magnesium deprivation ; Organoselenium Compounds - administration & dosage ; Organoselenium Compounds - pharmacology ; Oxidative stress ; Rodents ; Seizure threshold ; seizures ; Seizures - chemically induced ; Seizures - etiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2009-02, Vol.101 (3), p.317-321</ispartof><rights>Copyright © The Authors 2008</rights><rights>2009 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-14fc68411c68b788f7349f75bdbd99b502e750b9e3d210a6ccee0194c1dc82293</citedby><cites>FETCH-LOGICAL-c571t-14fc68411c68b788f7349f75bdbd99b502e750b9e3d210a6ccee0194c1dc82293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114508006752/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,777,781,882,27905,27906,55609</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21200799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21129231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02662275$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Maurois, Pierre</creatorcontrib><creatorcontrib>Pages, Nicole</creatorcontrib><creatorcontrib>Bac, Pierre</creatorcontrib><creatorcontrib>German-Fattal, Michèle</creatorcontrib><creatorcontrib>Agnani, Geneviève</creatorcontrib><creatorcontrib>Delplanque, Bernadette</creatorcontrib><creatorcontrib>Durlach, Jean</creatorcontrib><creatorcontrib>Poupaert, Jacques</creatorcontrib><creatorcontrib>Vamecq, Joseph</creatorcontrib><title>Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Magnesium deficiency may be induced by a diet impoverished in magnesium. This nutritional deficit promotes chronic inflammatory and oxidative stresses, hyperexcitability and, in mice, susceptibility to audiogenic seizures. Potentiation by low-magnesium concentrations of the opening of N-methyl-d-aspartate (NMDA) receptor/calcium channel in in vitro and ex vivo studies, and responsiveness to magnesium of in vivo brain injury states are now well established. By contrast, little or no specific attention has been, however, paid to the in vivo NMDA receptor function/excitability in magnesium deficiency. The present work reports for the first time that, in mice undergoing chronic nutritional deprivation in magnesium (35 v. 930 parts per million for 27 d in OF1 mice), NMDA-induced seizure threshold is significantly decreased (38 % of normal values). The attenuation in the drop of NMDA seizure threshold (percentage of reversal) was 58 and 20 % upon acute intraperitoneal administrations of magnesium chloride hexahydrate (28 mg magnesium/kg) and the antioxidant ebselen (20 mg/kg), respectively. In nutritionally magnesium-deprived animals, audiogenic seizures are completely prevented by these compound doses. Taken as a whole, our data emphasise that chronic magnesium deprivation in mice is a nutritional in vivo model for a lowered NMDA receptor activation threshold. This nutritional model responds remarkably to acute magnesium supply and moderately to acute antioxidant administration.</description><subject>Acoustic Stimulation - adverse effects</subject><subject>acute magnesium chloride hexahydrate</subject><subject>animal models</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - pharmacology</subject><subject>Audiogenic seizures</subject><subject>Azoles - administration & dosage</subject><subject>Azoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Calcium channels</subject><subject>chronic diseases</subject><subject>Convulsions & seizures</subject><subject>Diet</subject><subject>dietary mineral supplements</subject><subject>dietary minerals</subject><subject>dietary supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ebselen</subject><subject>Feeding. Feeding behavior</subject><subject>Food and Nutrition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>human diseases</subject><subject>human nutrition</subject><subject>Life Sciences</subject><subject>Magnesium</subject><subject>Magnesium - administration & dosage</subject><subject>Magnesium - pharmacology</subject><subject>magnesium chloride</subject><subject>Magnesium chloride hexahydrate</subject><subject>Magnesium Deficiency - complications</subject><subject>Magnesium Deficiency - drug therapy</subject><subject>Mice</subject><subject>N-methyl-D-aspartate receptor</subject><subject>N-methyl-D-aspartate-induced seizure</subject><subject>N-Methylaspartate - toxicity</subject><subject>nutrient deficiencies</subject><subject>Nutrition</subject><subject>Nutritional magnesium deprivation</subject><subject>Organoselenium Compounds - administration & dosage</subject><subject>Organoselenium Compounds - pharmacology</subject><subject>Oxidative stress</subject><subject>Rodents</subject><subject>Seizure threshold</subject><subject>seizures</subject><subject>Seizures - chemically induced</subject><subject>Seizures - etiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9ktGO1CAUQBujccfVD_BFiYkaH6pAS2kfN6vumowand3E-EJugc6wtjBCO7vjF_pZUjuOG40-ACn3cMq93CS5T_Bzggl_scAYc0JyhkuMC87ojWRGcs5SWhT0ZjIbw-kYP0juhHARP0uCq9vJASWEVjQjs-T72crrsHKtQr1D79JO96ttm75MIazB99Dr1Fg1SK1Q0ObbEGFkLOqM1GiwSvulM3aJ5Mo7aySyQ-9Nb5yFFnWwtDqYoUNKr73ZwLiPTECtu9Q-CqMH0CVs0findouie-1sMBs93gXk0OtrErAqjui4MiquCFRnrAm9_-kNd5NbDbRB39uth8n561dnx6fp_P3Jm-OjeSoZJ31K8kYWZU5InGtelg3P8qrhrFa1qqqaYao5w3WlM0UJhkJKrTGpckmULCmtssPk2eRdQStiWh34rXBgxOnRXIx7eCw-5WxDIvt0YtfefR106EVngtRtC1a7IYiSFFkZ341F8sl_SUooLvMKR_DRH-CFG3ws98hkZcYYLyJEJkh6F4LXzf6iBIuxc8RfnRPPPNiJh7rTan_iV6tE4PEOgCChbTxYacI1jkZlNRYonbj4NvpqHwf_RRQ840wUJx_E4iP79LlgC_E28g8nvgEnYOmj83xBMclwrA5l-WjMdulAV3ujlvp30v9O6AfMHfY2</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Maurois, Pierre</creator><creator>Pages, Nicole</creator><creator>Bac, Pierre</creator><creator>German-Fattal, Michèle</creator><creator>Agnani, Geneviève</creator><creator>Delplanque, Bernadette</creator><creator>Durlach, Jean</creator><creator>Poupaert, Jacques</creator><creator>Vamecq, Joseph</creator><general>Cambridge University Press</general><general>Cambridge University Press (CUP)</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>200902</creationdate><title>Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations</title><author>Maurois, Pierre ; Pages, Nicole ; Bac, Pierre ; German-Fattal, Michèle ; Agnani, Geneviève ; Delplanque, Bernadette ; Durlach, Jean ; Poupaert, Jacques ; Vamecq, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-14fc68411c68b788f7349f75bdbd99b502e750b9e3d210a6ccee0194c1dc82293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acoustic Stimulation - adverse effects</topic><topic>acute magnesium chloride hexahydrate</topic><topic>animal models</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - pharmacology</topic><topic>Audiogenic seizures</topic><topic>Azoles - administration & dosage</topic><topic>Azoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Calcium channels</topic><topic>chronic diseases</topic><topic>Convulsions & seizures</topic><topic>Diet</topic><topic>dietary mineral supplements</topic><topic>dietary minerals</topic><topic>dietary supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ebselen</topic><topic>Feeding. Feeding behavior</topic><topic>Food and Nutrition</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>human diseases</topic><topic>human nutrition</topic><topic>Life Sciences</topic><topic>Magnesium</topic><topic>Magnesium - administration & dosage</topic><topic>Magnesium - pharmacology</topic><topic>magnesium chloride</topic><topic>Magnesium chloride hexahydrate</topic><topic>Magnesium Deficiency - complications</topic><topic>Magnesium Deficiency - drug therapy</topic><topic>Mice</topic><topic>N-methyl-D-aspartate receptor</topic><topic>N-methyl-D-aspartate-induced seizure</topic><topic>N-Methylaspartate - toxicity</topic><topic>nutrient deficiencies</topic><topic>Nutrition</topic><topic>Nutritional magnesium deprivation</topic><topic>Organoselenium Compounds - administration & dosage</topic><topic>Organoselenium Compounds - pharmacology</topic><topic>Oxidative stress</topic><topic>Rodents</topic><topic>Seizure threshold</topic><topic>seizures</topic><topic>Seizures - chemically induced</topic><topic>Seizures - etiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maurois, Pierre</creatorcontrib><creatorcontrib>Pages, Nicole</creatorcontrib><creatorcontrib>Bac, Pierre</creatorcontrib><creatorcontrib>German-Fattal, Michèle</creatorcontrib><creatorcontrib>Agnani, Geneviève</creatorcontrib><creatorcontrib>Delplanque, Bernadette</creatorcontrib><creatorcontrib>Durlach, Jean</creatorcontrib><creatorcontrib>Poupaert, Jacques</creatorcontrib><creatorcontrib>Vamecq, Joseph</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maurois, Pierre</au><au>Pages, Nicole</au><au>Bac, Pierre</au><au>German-Fattal, Michèle</au><au>Agnani, Geneviève</au><au>Delplanque, Bernadette</au><au>Durlach, Jean</au><au>Poupaert, Jacques</au><au>Vamecq, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2009-02</date><risdate>2009</risdate><volume>101</volume><issue>3</issue><spage>317</spage><epage>321</epage><pages>317-321</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Magnesium deficiency may be induced by a diet impoverished in magnesium. This nutritional deficit promotes chronic inflammatory and oxidative stresses, hyperexcitability and, in mice, susceptibility to audiogenic seizures. Potentiation by low-magnesium concentrations of the opening of N-methyl-d-aspartate (NMDA) receptor/calcium channel in in vitro and ex vivo studies, and responsiveness to magnesium of in vivo brain injury states are now well established. By contrast, little or no specific attention has been, however, paid to the in vivo NMDA receptor function/excitability in magnesium deficiency. The present work reports for the first time that, in mice undergoing chronic nutritional deprivation in magnesium (35 v. 930 parts per million for 27 d in OF1 mice), NMDA-induced seizure threshold is significantly decreased (38 % of normal values). The attenuation in the drop of NMDA seizure threshold (percentage of reversal) was 58 and 20 % upon acute intraperitoneal administrations of magnesium chloride hexahydrate (28 mg magnesium/kg) and the antioxidant ebselen (20 mg/kg), respectively. In nutritionally magnesium-deprived animals, audiogenic seizures are completely prevented by these compound doses. Taken as a whole, our data emphasise that chronic magnesium deprivation in mice is a nutritional in vivo model for a lowered NMDA receptor activation threshold. This nutritional model responds remarkably to acute magnesium supply and moderately to acute antioxidant administration.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>21129231</pmid><doi>10.1017/S0007114508006752</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2009-02, Vol.101 (3), p.317-321 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02662275v1 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry; Cambridge University Press Journals Complete |
| subjects | Acoustic Stimulation - adverse effects acute magnesium chloride hexahydrate animal models Animals Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Audiogenic seizures Azoles - administration & dosage Azoles - pharmacology Biological and medical sciences Calcium channels chronic diseases Convulsions & seizures Diet dietary mineral supplements dietary minerals dietary supplements Dose-Response Relationship, Drug Ebselen Feeding. Feeding behavior Food and Nutrition Fundamental and applied biological sciences. Psychology human diseases human nutrition Life Sciences Magnesium Magnesium - administration & dosage Magnesium - pharmacology magnesium chloride Magnesium chloride hexahydrate Magnesium Deficiency - complications Magnesium Deficiency - drug therapy Mice N-methyl-D-aspartate receptor N-methyl-D-aspartate-induced seizure N-Methylaspartate - toxicity nutrient deficiencies Nutrition Nutritional magnesium deprivation Organoselenium Compounds - administration & dosage Organoselenium Compounds - pharmacology Oxidative stress Rodents Seizure threshold seizures Seizures - chemically induced Seizures - etiology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T05%3A20%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Threshold%20to%20N-methyl-D-aspartate-induced%20seizures%20in%20mice%20undergoing%20chronic%20nutritional%20magnesium%20deprivation%20is%20lowered%20in%20a%20way%20partly%20responsive%20to%20acute%20magnesium%20and%20antioxidant%20administrations&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Maurois,%20Pierre&rft.date=2009-02&rft.volume=101&rft.issue=3&rft.spage=317&rft.epage=321&rft.pages=317-321&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114508006752&rft_dat=%3Cproquest_hal_p%3E816386755%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213835576&rft_id=info:pmid/21129231&rft_cupid=10_1017_S0007114508006752&rfr_iscdi=true |