Effects of Illicit Dexamethasone upon Hepatic Drug Metabolizing Enzymes and Related Transcription Factors mRNAs and Their Potential Use As Biomarkers in Cattle

In cattle fattening, the illicit use of growth promoters (GPs) represents a major problem. The synthetic corticosteroid dexamethasone (DEX) is the GP mostly used, alone or in combination with other steroids or β-agonists. Recently, GPs were shown to disrupt some cattle cytochromes P450 (CYPs) at the...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2010-01, Vol.58 (2), p.1342-1349
Hauptverfasser:	Giantin, Mery, Lopparelli, Rosa M, Zancanella, Vanessa, Martin, Pascal G, Polizzi, Arnaud, Gallina, Guglielmo, Gottardo, Flaviana, Montesissa, Clara, Ravarotto, Licia, Pineau, Thierry, Dacasto, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers - analysis Biomarkers - metabolism Cattle - genetics Cattle - growth & development Cattle - metabolism Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Dexamethasone - administration & dosage Dexamethasone - metabolism Food engineering Food industries Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Glutathione Transferase - genetics Glutathione Transferase - metabolism Life Sciences Liver - chemistry Liver - drug effects Liver - enzymology Liver - metabolism Male RNA, Messenger - genetics RNA, Messenger - metabolism Substance Abuse Detection - methods Toxicology in Agriculture and Food Transcription Factors - genetics Transcription Factors - metabolism
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