HLA-B27 rats develop osteopaenia through increased bone resorption without any change in bone formation

Osteopaenia is a common complication of inflammatory bowel diseases (IBD). However, the mechanisms of bone loss are still the subject of debate. The aims of this study were to investigate bone loss in HLA-B27 transgenic rats, a spontaneous model of colitis and to compare the results provided by the...

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Veröffentlicht in:	Journal of musculoskeletal & neuronal interactions 2008-07, Vol.8 (3), p.251-256
Hauptverfasser:	Papet, I, El Yousfi, M, Godin, J P, Mermoud, A F, Davicco, M J, Coxam, V, Breuille, D, Obled, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - urine Animals Biomarkers - blood Biomarkers - urine Bone Density Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - etiology Bone Diseases, Metabolic - physiopathology Bone Diseases, Metabolic - urine Bone Remodeling Bone Resorption - complications Bone Resorption - urine Colitis - complications Colitis - genetics Disease Models, Animal Epiphyses - metabolism Femur - physiopathology HLA-B27 Antigen - genetics HLA-B27 Antigen - metabolism Life Sciences Male Osteocalcin - blood Osteogenesis Protein Biosynthesis Rats Rats, Inbred F344 Rats, Transgenic Tensile Strength Tibia - metabolism
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