Biological Functions and Metabolism of Oleoylethanolamide
The present review is focused on the metabolism and the emerging roles of oleoylethanolamide (OEA) with emphasis on its effects on food intake control and lipid metabolism. The biological mechanism of action, including a non-genomic effect mediated through peroxisome proliferator-activated receptor...
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| Veröffentlicht in: | Lipids 2008-10, Vol.43 (10), p.887-894 |
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| creator | Thabuis, Clémentine Tissot-Favre, Delphine Bezelgues, Jean-Baptiste Martin, Jean-Charles Cruz-Hernandez, Cristina Dionisi, Fabiola Destaillats, Frédéric |
| description | The present review is focused on the metabolism and the emerging roles of oleoylethanolamide (OEA) with emphasis on its effects on food intake control and lipid metabolism. The biological mechanism of action, including a non-genomic effect mediated through peroxisome proliferator-activated receptor alpha (PPAR-α) and transient receptor potential vanilloid type 1 (TRPV1) receptor, is discussed. The research related to fatty acid ethanolamides has been focused until recently on anandamide and its interaction with cannabinoid receptor subtype 1. The roles of other N-acyl ethanolamine fatty acid derivatives have been neglected until it was demonstrated that OEA can modulate food intake control through interaction with PPAR-α. Further investigations demonstrated that OEA modulates lipid and glucose metabolism, and recent study confirmed that OEA is an antagonist of TRVP1. It has been demonstrated that OEA has beneficial effects on health by inducing food intake control, lipid β-oxidation, body weight loss and analgesic effects. The investigation of the mechanism of action revealed that OEA activates PPAR-α and stimulates the vagal nerve through the capsaicin receptor TRPV1. Pre-clinical studies showed that OEA remains active when administered orally. |
| doi_str_mv | 10.1007/s11745-008-3217-y |
| format | Article |
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The biological mechanism of action, including a non-genomic effect mediated through peroxisome proliferator-activated receptor alpha (PPAR-α) and transient receptor potential vanilloid type 1 (TRPV1) receptor, is discussed. The research related to fatty acid ethanolamides has been focused until recently on anandamide and its interaction with cannabinoid receptor subtype 1. The roles of other N-acyl ethanolamine fatty acid derivatives have been neglected until it was demonstrated that OEA can modulate food intake control through interaction with PPAR-α. Further investigations demonstrated that OEA modulates lipid and glucose metabolism, and recent study confirmed that OEA is an antagonist of TRVP1. It has been demonstrated that OEA has beneficial effects on health by inducing food intake control, lipid β-oxidation, body weight loss and analgesic effects. The investigation of the mechanism of action revealed that OEA activates PPAR-α and stimulates the vagal nerve through the capsaicin receptor TRPV1. Pre-clinical studies showed that OEA remains active when administered orally.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-008-3217-y</identifier><identifier>PMID: 18704536</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Animals ; Biochemistry ; Biochemistry, Molecular Biology ; Biomedical and Life Sciences ; Body weight ; Endocannabinoids ; Energy metabolism ; ethanolamine ; Fatty acids ; Food ; Food intake ; Humans ; Life Sciences ; Lipid Metabolism ; Lipidology ; literature reviews ; Medical Biochemistry ; Medicinal Chemistry ; Microbial Genetics and Genomics ; Neurochemistry ; Nutrition ; N‐acyl fatty acid ethanolamine ; Oleic Acids - chemistry ; Oleic Acids - metabolism ; Oleoylethanolamide ; peroxisome proliferator-activated receptor-alpha ; PPAR alpha - metabolism ; Review ; transient receptor potential vanilloid receptor ; TRPV Cation Channels - metabolism</subject><ispartof>Lipids, 2008-10, Vol.43 (10), p.887-894</ispartof><rights>AOCS 2008</rights><rights>2008 American Oil Chemists' Society (AOCS)</rights><rights>Copyright AOCS Press Oct 2008</rights><rights>Copyright</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584Y-dd841dfc28bc9e970df491b653d6d12727c047075465e2ca97838e35641761143</citedby><cites>FETCH-LOGICAL-c584Y-dd841dfc28bc9e970df491b653d6d12727c047075465e2ca97838e35641761143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11745-008-3217-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11745-008-3217-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18704536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02658710$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Thabuis, Clémentine</creatorcontrib><creatorcontrib>Tissot-Favre, Delphine</creatorcontrib><creatorcontrib>Bezelgues, Jean-Baptiste</creatorcontrib><creatorcontrib>Martin, Jean-Charles</creatorcontrib><creatorcontrib>Cruz-Hernandez, Cristina</creatorcontrib><creatorcontrib>Dionisi, Fabiola</creatorcontrib><creatorcontrib>Destaillats, Frédéric</creatorcontrib><title>Biological Functions and Metabolism of Oleoylethanolamide</title><title>Lipids</title><addtitle>Lipids</addtitle><addtitle>Lipids</addtitle><description>The present review is focused on the metabolism and the emerging roles of oleoylethanolamide (OEA) with emphasis on its effects on food intake control and lipid metabolism. The biological mechanism of action, including a non-genomic effect mediated through peroxisome proliferator-activated receptor alpha (PPAR-α) and transient receptor potential vanilloid type 1 (TRPV1) receptor, is discussed. The research related to fatty acid ethanolamides has been focused until recently on anandamide and its interaction with cannabinoid receptor subtype 1. The roles of other N-acyl ethanolamine fatty acid derivatives have been neglected until it was demonstrated that OEA can modulate food intake control through interaction with PPAR-α. Further investigations demonstrated that OEA modulates lipid and glucose metabolism, and recent study confirmed that OEA is an antagonist of TRVP1. It has been demonstrated that OEA has beneficial effects on health by inducing food intake control, lipid β-oxidation, body weight loss and analgesic effects. The investigation of the mechanism of action revealed that OEA activates PPAR-α and stimulates the vagal nerve through the capsaicin receptor TRPV1. Pre-clinical studies showed that OEA remains active when administered orally.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Body weight</subject><subject>Endocannabinoids</subject><subject>Energy metabolism</subject><subject>ethanolamine</subject><subject>Fatty acids</subject><subject>Food</subject><subject>Food intake</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lipid Metabolism</subject><subject>Lipidology</subject><subject>literature reviews</subject><subject>Medical Biochemistry</subject><subject>Medicinal Chemistry</subject><subject>Microbial Genetics and Genomics</subject><subject>Neurochemistry</subject><subject>Nutrition</subject><subject>N‐acyl fatty acid ethanolamine</subject><subject>Oleic Acids - chemistry</subject><subject>Oleic Acids - metabolism</subject><subject>Oleoylethanolamide</subject><subject>peroxisome proliferator-activated receptor-alpha</subject><subject>PPAR alpha - 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The biological mechanism of action, including a non-genomic effect mediated through peroxisome proliferator-activated receptor alpha (PPAR-α) and transient receptor potential vanilloid type 1 (TRPV1) receptor, is discussed. The research related to fatty acid ethanolamides has been focused until recently on anandamide and its interaction with cannabinoid receptor subtype 1. The roles of other N-acyl ethanolamine fatty acid derivatives have been neglected until it was demonstrated that OEA can modulate food intake control through interaction with PPAR-α. Further investigations demonstrated that OEA modulates lipid and glucose metabolism, and recent study confirmed that OEA is an antagonist of TRVP1. It has been demonstrated that OEA has beneficial effects on health by inducing food intake control, lipid β-oxidation, body weight loss and analgesic effects. The investigation of the mechanism of action revealed that OEA activates PPAR-α and stimulates the vagal nerve through the capsaicin receptor TRPV1. Pre-clinical studies showed that OEA remains active when administered orally.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>18704536</pmid><doi>10.1007/s11745-008-3217-y</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Lipids, 2008-10, Vol.43 (10), p.887-894 |
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| language | eng |
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| subjects | Animals Biochemistry Biochemistry, Molecular Biology Biomedical and Life Sciences Body weight Endocannabinoids Energy metabolism ethanolamine Fatty acids Food Food intake Humans Life Sciences Lipid Metabolism Lipidology literature reviews Medical Biochemistry Medicinal Chemistry Microbial Genetics and Genomics Neurochemistry Nutrition N‐acyl fatty acid ethanolamine Oleic Acids - chemistry Oleic Acids - metabolism Oleoylethanolamide peroxisome proliferator-activated receptor-alpha PPAR alpha - metabolism Review transient receptor potential vanilloid receptor TRPV Cation Channels - metabolism |
| title | Biological Functions and Metabolism of Oleoylethanolamide |
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