The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: Presence and sensitivity to fosmidomycin

The apicoplast is a recently discovered, plastid-like organelle present in most apicomplexa. The methylerythritol phosphate (MEP) pathway involved in isoprenoid biosynthesis is one of the metabolic pathways associated with the apicoplast, and is a new promising therapeutic target in Plasmodium falci...

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Veröffentlicht in:	Experimental parasitology 2007-08, Vol.116 (4), p.375-384
Hauptverfasser:	Clastre, Marc, Goubard, Armelle, Prel, Anne, Mincheva, Zoia, Viaud-Massuart, Marie-Claude, Bout, Daniel, Rideau, Marc, Velge-Roussel, Florence, Laurent, Fabrice
Format:	Artikel
Sprache:	eng
Schlagworte:	4-diphosphocytidyl methylerythritol synthase Animals Apicomplexa Biological and medical sciences Cell Line Cell Survival - drug effects Chickens CMS Coccidia Coccidia - drug effects Coccidia - genetics Coccidia - growth & development Coccidia - metabolism Cryptosporidium - drug effects Cryptosporidium - genetics Cryptosporidium - growth & development Cryptosporidium - metabolism Cryptosporidium hominis Cryptosporidium parvum Cryptosporidium parvum - drug effects Cryptosporidium parvum - genetics Cryptosporidium parvum - growth & development Cryptosporidium parvum - metabolism dimethylallyl diphosphate DMAPP E. tenella deoxyxylulose 5-phosphate synthase E. tenella methylerythritol 2,4-cyclodiphosphate synthase Eimeria tenella Eimeria tenella - drug effects Eimeria tenella - genetics Eimeria tenella - growth & development Eimeria tenella - metabolism Erythritol - genetics Erythritol - metabolism Etdxs Etmecs Fosfomycin - analogs & derivatives Fosfomycin - pharmacology Fosmidomycin Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - genetics Genome, Protozoan Herbicides - pharmacology IPP IPPI isopentenyl diphosphate isopentenyl diphosphate isomerase Isoprenoid biosynthesis Isoxazoles - pharmacology Life cycle. Host-agent relationship. Pathogenesis Life Sciences MEP methylerythritol phosphate mevalonic acid Mice Mice, Inbred CBA MVA Oxazolidinones - pharmacology Plasmodium falciparum Protozoa reverse transcription-polymerase chain reaction RT-PCR T. gondii deoxyxylulose 5-phosphate reductoisomerase T. gondii hydroxymethylbutenyl 4-diphosphate reductase T. gondii methylerythritol 2,4-cyclodiphosphate synthase Terpenes - metabolism Tgdxr Tghdr Tgmecs Toxoplasma - drug effects Toxoplasma - genetics Toxoplasma - growth & development Toxoplasma - metabolism Toxoplasma gondii
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