Age-Associated Discrepancy between Measured and Calculated Bioavailable Testosterone in Men
Bioavailable testosterone (BT) concentration is considered the best marker for evaluating testicular function in men. The decrease of BT in older men is more pronounced than the decrease in total testosterone because of the parallel increase in sex hormone-binding globulin (SHBG) concentrations. Mea...
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 2007-04, Vol.53 (4), p.723-728 |
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| creator | Dechaud, Henri Denuziere, Anne Rinaldi, Sabina Bocquet, Julien Lejeune, Herve Pugeat, Michel |
| description | Bioavailable testosterone (BT) concentration is considered the best marker for evaluating testicular function in men. The decrease of BT in older men is more pronounced than the decrease in total testosterone because of the parallel increase in sex hormone-binding globulin (SHBG) concentrations. Measurement of BT is therefore crucial for the diagnosis of hypoandrogenism in the aging male population.
We compared BT concentrations measured by a specific RIA after ammonium sulfate precipitation (BT(meas)) with those obtained by theoretical calculations (BT(cal)) in plasma samples from 694 young men (14 to 49 years old) and 51 older men (50 to 81 years old). We based theoretical calculations on Vermeulen's simplified mass equation using total testosterone and SHBG concentrations.
BT(cal) and BT(meas) correlated significantly in young (Pearson r = 0.87) and aging (r = 0.89) men, but the BT(cal):BT(meas) ratio differed markedly between the 2 groups (2.28 vs 3.48; P |
| doi_str_mv | 10.1373/clinchem.2006.077362 |
| format | Article |
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We compared BT concentrations measured by a specific RIA after ammonium sulfate precipitation (BT(meas)) with those obtained by theoretical calculations (BT(cal)) in plasma samples from 694 young men (14 to 49 years old) and 51 older men (50 to 81 years old). We based theoretical calculations on Vermeulen's simplified mass equation using total testosterone and SHBG concentrations.
BT(cal) and BT(meas) correlated significantly in young (Pearson r = 0.87) and aging (r = 0.89) men, but the BT(cal):BT(meas) ratio differed markedly between the 2 groups (2.28 vs 3.48; P <0.001).
In men, there is an age-associated discrepancy between calculated and measured BT concentrations. We suggest some hypotheses for the discrepancy, but additional studies will be performed to finally elucidate this difference in results and to determine the most appropriate method for BT measurements in older men.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1373/clinchem.2006.077362</identifier><identifier>PMID: 17317886</identifier><identifier>CODEN: CLCHAU</identifier><language>eng</language><publisher>Washington, DC: Am Assoc Clin Chem</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Aging - metabolism ; Algorithms ; Ammonium ; Ammonium Sulfate ; Analytical, structural and metabolic biochemistry ; Androgens ; Binding sites ; Biological and medical sciences ; Chemical Precipitation ; Computer Science ; Fundamental and applied biological sciences. Psychology ; Humans ; Indicators and Reagents ; Investigative techniques, diagnostic techniques (general aspects) ; Life Sciences ; Male ; Medical sciences ; Men ; Methods ; Middle Aged ; Patients ; Plasma ; Radioimmunoassay ; Reproductive health ; Sensitivity analysis ; Testosterone ; Testosterone - blood</subject><ispartof>Clinical chemistry (Baltimore, Md.), 2007-04, Vol.53 (4), p.723-728</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright American Association for Clinical Chemistry Apr 2007</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-e2c91f0161dca8325c8857eeaa276e643728f3948147fc0827ca1e7b22671afe3</citedby><cites>FETCH-LOGICAL-c472t-e2c91f0161dca8325c8857eeaa276e643728f3948147fc0827ca1e7b22671afe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18669158$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17317886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02655751$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dechaud, Henri</creatorcontrib><creatorcontrib>Denuziere, Anne</creatorcontrib><creatorcontrib>Rinaldi, Sabina</creatorcontrib><creatorcontrib>Bocquet, Julien</creatorcontrib><creatorcontrib>Lejeune, Herve</creatorcontrib><creatorcontrib>Pugeat, Michel</creatorcontrib><title>Age-Associated Discrepancy between Measured and Calculated Bioavailable Testosterone in Men</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>Bioavailable testosterone (BT) concentration is considered the best marker for evaluating testicular function in men. The decrease of BT in older men is more pronounced than the decrease in total testosterone because of the parallel increase in sex hormone-binding globulin (SHBG) concentrations. Measurement of BT is therefore crucial for the diagnosis of hypoandrogenism in the aging male population.
We compared BT concentrations measured by a specific RIA after ammonium sulfate precipitation (BT(meas)) with those obtained by theoretical calculations (BT(cal)) in plasma samples from 694 young men (14 to 49 years old) and 51 older men (50 to 81 years old). We based theoretical calculations on Vermeulen's simplified mass equation using total testosterone and SHBG concentrations.
BT(cal) and BT(meas) correlated significantly in young (Pearson r = 0.87) and aging (r = 0.89) men, but the BT(cal):BT(meas) ratio differed markedly between the 2 groups (2.28 vs 3.48; P <0.001).
In men, there is an age-associated discrepancy between calculated and measured BT concentrations. We suggest some hypotheses for the discrepancy, but additional studies will be performed to finally elucidate this difference in results and to determine the most appropriate method for BT measurements in older men.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Algorithms</subject><subject>Ammonium</subject><subject>Ammonium Sulfate</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Androgens</subject><subject>Binding sites</subject><subject>Biological and medical sciences</subject><subject>Chemical Precipitation</subject><subject>Computer Science</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Indicators and Reagents</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Plasma</subject><subject>Radioimmunoassay</subject><subject>Reproductive health</subject><subject>Sensitivity analysis</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><issn>0009-9147</issn><issn>1530-8561</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkc2O0zAURi0EYjoDb4BQhAQSixT_JL7OspSBQSpiM6xYWLfuzdQjNyl2MtG8PS4tVGJl2T7ftT8dxl4JPhcK1AcXfOe2tJtLzvWcAygtn7CZqBUvTa3FUzbjnDdlIyq4YJcp3edtBUY_ZxcClABj9Iz9XNxRuUipdx4H2hSffHKR9ti5x2JNw0TUFd8I0xjzJXabYonBjeEP-9H3-IA-4DpQcUtp6NNAse-o8IdQ94I9azEkenlar9iPz9e3y5ty9f3L1-ViVboK5FCSdI1oudBi49AoWTtjaiBClKBJVwqkaVVTmVykddxIcCgI1lJqENiSumLvj3O3GOw--h3GR9ujtzeLlT2ccanrGmrxIDL77sjuY_9rzH-2u9yYQsCO-jFZ4KriWpsMvvkPvO_H2OUeVgrVNAYkZKg6Qi72KUVq_z0vuD1Ysn8t2YMle7SUY69Ps8f1jjbn0ElLBt6eAEwOQxuzD5_OnNG6EbU5c1t_t518JJt2GEIeK-w0TbWylQWp1G8ZC6g4</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Dechaud, Henri</creator><creator>Denuziere, Anne</creator><creator>Rinaldi, Sabina</creator><creator>Bocquet, Julien</creator><creator>Lejeune, Herve</creator><creator>Pugeat, Michel</creator><general>Am Assoc Clin Chem</general><general>American Association for Clinical Chemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7QO</scope><scope>7RV</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20070401</creationdate><title>Age-Associated Discrepancy between Measured and Calculated Bioavailable Testosterone in Men</title><author>Dechaud, Henri ; Denuziere, Anne ; Rinaldi, Sabina ; Bocquet, Julien ; Lejeune, Herve ; Pugeat, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-e2c91f0161dca8325c8857eeaa276e643728f3948147fc0827ca1e7b22671afe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Algorithms</topic><topic>Ammonium</topic><topic>Ammonium Sulfate</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Androgens</topic><topic>Binding sites</topic><topic>Biological and medical sciences</topic><topic>Chemical Precipitation</topic><topic>Computer Science</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Indicators and Reagents</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Plasma</topic><topic>Radioimmunoassay</topic><topic>Reproductive health</topic><topic>Sensitivity analysis</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dechaud, Henri</creatorcontrib><creatorcontrib>Denuziere, Anne</creatorcontrib><creatorcontrib>Rinaldi, Sabina</creatorcontrib><creatorcontrib>Bocquet, Julien</creatorcontrib><creatorcontrib>Lejeune, Herve</creatorcontrib><creatorcontrib>Pugeat, Michel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dechaud, Henri</au><au>Denuziere, Anne</au><au>Rinaldi, Sabina</au><au>Bocquet, Julien</au><au>Lejeune, Herve</au><au>Pugeat, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-Associated Discrepancy between Measured and Calculated Bioavailable Testosterone in Men</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>53</volume><issue>4</issue><spage>723</spage><epage>728</epage><pages>723-728</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><coden>CLCHAU</coden><abstract>Bioavailable testosterone (BT) concentration is considered the best marker for evaluating testicular function in men. The decrease of BT in older men is more pronounced than the decrease in total testosterone because of the parallel increase in sex hormone-binding globulin (SHBG) concentrations. Measurement of BT is therefore crucial for the diagnosis of hypoandrogenism in the aging male population.
We compared BT concentrations measured by a specific RIA after ammonium sulfate precipitation (BT(meas)) with those obtained by theoretical calculations (BT(cal)) in plasma samples from 694 young men (14 to 49 years old) and 51 older men (50 to 81 years old). We based theoretical calculations on Vermeulen's simplified mass equation using total testosterone and SHBG concentrations.
BT(cal) and BT(meas) correlated significantly in young (Pearson r = 0.87) and aging (r = 0.89) men, but the BT(cal):BT(meas) ratio differed markedly between the 2 groups (2.28 vs 3.48; P <0.001).
In men, there is an age-associated discrepancy between calculated and measured BT concentrations. We suggest some hypotheses for the discrepancy, but additional studies will be performed to finally elucidate this difference in results and to determine the most appropriate method for BT measurements in older men.</abstract><cop>Washington, DC</cop><pub>Am Assoc Clin Chem</pub><pmid>17317886</pmid><doi>10.1373/clinchem.2006.077362</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Aging Aging - metabolism Algorithms Ammonium Ammonium Sulfate Analytical, structural and metabolic biochemistry Androgens Binding sites Biological and medical sciences Chemical Precipitation Computer Science Fundamental and applied biological sciences. Psychology Humans Indicators and Reagents Investigative techniques, diagnostic techniques (general aspects) Life Sciences Male Medical sciences Men Methods Middle Aged Patients Plasma Radioimmunoassay Reproductive health Sensitivity analysis Testosterone Testosterone - blood |
| title | Age-Associated Discrepancy between Measured and Calculated Bioavailable Testosterone in Men |
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