Kidney transplant and cryptic hepatitis
Blood test results showed: high concen trations of ã-glutamyltranspeptidase (231 IU/L), aspartate aminotransferase (AST; 1026 IU/L), alanine amino transferase (704 IU/L), and total alkaline phosphatase (414 IU/L). Restoration of immune function, on withdrawal of immunosuppressive therapy, introduced...
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| Veröffentlicht in: | The Lancet (British edition) 2009-06, Vol.373 (9680), p.2082-2082 |
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| creator | Chaubo, Catherine, Dr Hot, Arnaud, MD Chevallier-Queyron, Philippe, MD Ritter, Jacques, MD Scoazec, Jean-Yves, MD Zoulim, Fabien, MD Karamé, Alexandre, MD Brunet, Maria, MD Touraine, Jean-Louis, MD Morelon, Emmanuel, MD |
| description | Blood test results showed: high concen trations of ã-glutamyltranspeptidase (231 IU/L), aspartate aminotransferase (AST; 1026 IU/L), alanine amino transferase (704 IU/L), and total alkaline phosphatase (414 IU/L). Restoration of immune function, on withdrawal of immunosuppressive therapy, introduced a new imbalance between host immunity and virus infection.3 This experience has also been reported for HBV infections in HIV-infected patients after introduction of highly active antiretroviral therapy4 and in patients receiving chemotherapy for cancer.5 In our patient, it resulted in rapid immune-mediated destruction of HBVinfected hepatocytes, manifested as acute hepatitis. |
| doi_str_mv | 10.1016/S0140-6736(09)60739-X |
| format | Article |
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Restoration of immune function, on withdrawal of immunosuppressive therapy, introduced a new imbalance between host immunity and virus infection.3 This experience has also been reported for HBV infections in HIV-infected patients after introduction of highly active antiretroviral therapy4 and in patients receiving chemotherapy for cancer.5 In our patient, it resulted in rapid immune-mediated destruction of HBVinfected hepatocytes, manifested as acute hepatitis.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(09)60739-X</identifier><identifier>PMID: 19524783</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Acute Disease ; Amino Acid Substitution - genetics ; Antiretroviral agents ; Biological and medical sciences ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Hepatitis ; Hepatitis B virus - physiology ; Hepatitis B, Chronic - diagnosis ; Hepatitis B, Chronic - etiology ; Humans ; Immune response ; Immunocompromised Host ; Immunosuppressive Agents - adverse effects ; Internal Medicine ; Kidney diseases ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Kidney Transplantation - immunology ; Life Sciences ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical research ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Patient care planning ; Patients ; Recurrence ; Transplantation Immunology ; Transplants & implants ; Tropical diseases ; Virus Activation</subject><ispartof>The Lancet (British edition), 2009-06, Vol.373 (9680), p.2082-2082</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jun 13-Jun 19, 2009</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-dbb6b098742b56e3708712b2fb2a1e85c0192d4dc141c432762a7234e950df713</citedby><cites>FETCH-LOGICAL-c509t-dbb6b098742b56e3708712b2fb2a1e85c0192d4dc141c432762a7234e950df713</cites><orcidid>0000-0002-2245-0083</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199045584?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21556891$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19524783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02654384$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaubo, Catherine, Dr</creatorcontrib><creatorcontrib>Hot, Arnaud, MD</creatorcontrib><creatorcontrib>Chevallier-Queyron, Philippe, MD</creatorcontrib><creatorcontrib>Ritter, Jacques, MD</creatorcontrib><creatorcontrib>Scoazec, Jean-Yves, MD</creatorcontrib><creatorcontrib>Zoulim, Fabien, MD</creatorcontrib><creatorcontrib>Karamé, Alexandre, MD</creatorcontrib><creatorcontrib>Brunet, Maria, MD</creatorcontrib><creatorcontrib>Touraine, Jean-Louis, MD</creatorcontrib><creatorcontrib>Morelon, Emmanuel, MD</creatorcontrib><title>Kidney transplant and cryptic hepatitis</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Blood test results showed: high concen trations of ã-glutamyltranspeptidase (231 IU/L), aspartate aminotransferase (AST; 1026 IU/L), alanine amino transferase (704 IU/L), and total alkaline phosphatase (414 IU/L). Restoration of immune function, on withdrawal of immunosuppressive therapy, introduced a new imbalance between host immunity and virus infection.3 This experience has also been reported for HBV infections in HIV-infected patients after introduction of highly active antiretroviral therapy4 and in patients receiving chemotherapy for cancer.5 In our patient, it resulted in rapid immune-mediated destruction of HBVinfected hepatocytes, manifested as acute hepatitis.</description><subject>Acute Disease</subject><subject>Amino Acid Substitution - genetics</subject><subject>Antiretroviral agents</subject><subject>Biological and medical sciences</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Hepatitis</subject><subject>Hepatitis B virus - physiology</subject><subject>Hepatitis B, Chronic - diagnosis</subject><subject>Hepatitis B, Chronic - etiology</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunocompromised Host</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Internal Medicine</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - immunology</subject><subject>Life Sciences</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. 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Restoration of immune function, on withdrawal of immunosuppressive therapy, introduced a new imbalance between host immunity and virus infection.3 This experience has also been reported for HBV infections in HIV-infected patients after introduction of highly active antiretroviral therapy4 and in patients receiving chemotherapy for cancer.5 In our patient, it resulted in rapid immune-mediated destruction of HBVinfected hepatocytes, manifested as acute hepatitis.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19524783</pmid><doi>10.1016/S0140-6736(09)60739-X</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2245-0083</orcidid></addata></record> |
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| subjects | Acute Disease Amino Acid Substitution - genetics Antiretroviral agents Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen General aspects Hepatitis Hepatitis B virus - physiology Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - etiology Humans Immune response Immunocompromised Host Immunosuppressive Agents - adverse effects Internal Medicine Kidney diseases Kidney transplantation Kidney Transplantation - adverse effects Kidney Transplantation - immunology Life Sciences Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical research Medical sciences Middle Aged Other diseases. Semiology Patient care planning Patients Recurrence Transplantation Immunology Transplants & implants Tropical diseases Virus Activation |
| title | Kidney transplant and cryptic hepatitis |
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