Excess body weight and second primary cancer risk after breast cancer: a systematic review and meta-analysis of prospective studies
Several observational studies have investigated the role of body mass index (BMI) in second primary cancer incidence in women with breast cancer. We conducted a systematic review and meta-analysis of the evidence to assess the strength of this association. PubMed and Embase were searched for observa...
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| Veröffentlicht in: | Breast cancer research and treatment 2012-10, Vol.135 (3), p.647-654 |
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| creator | Druesne-Pecollo, Nathalie Touvier, Mathilde Barrandon, Emilie Chan, Doris S. M. Norat, Teresa Zelek, Laurent Hercberg, Serge Latino-Martel, Paule |
| description | Several observational studies have investigated the role of body mass index (BMI) in second primary cancer incidence in women with breast cancer. We conducted a systematic review and meta-analysis of the evidence to assess the strength of this association. PubMed and Embase were searched for observational studies up to May 2012, and the reference lists of studies included in the analysis were examined. Random effects models were used to estimate summary relative risks (RRs) and 95 % confidence intervals (CIs). Thirteen prospective studies, five cohort and eight nested case–control studies, were included. In categorical meta-analyses of BMI, obesity was associated to significantly increased risks of contralateral breast (RR = 1.37, 95 % CI: 1.20–1.57), breast (RR = 1.40, 95 % CI: 1.24–1.58), endometrial (RR = 1.96, 95 % CI: 1.43–2.70), and colorectal (RR = 1.89, 95 % CI: 1.28–2.79) second primary cancers. For a BMI increase of 5 kg/m
2
, dose–response meta-analyses resulted in significantly increased RRs of 1.12 (95 % CI: 1.06–1.20) and 1.14 (95 % CI: 1.07–1.21) for contralateral breast and breast second primary cancers, respectively. The summary RR for endometrial second primary cancers was 1.46 (95 % CI: 1.17–1.83) for a 5-unit increment. This result emphasizes the importance of prevention policies aiming to reduce overweight and obesity prevalence. Clinical trials in breast cancer patients with excess body weight evaluating the effect of normal weight restoration on second primary cancer incidence are needed. |
| doi_str_mv | 10.1007/s10549-012-2187-1 |
| format | Article |
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, dose–response meta-analyses resulted in significantly increased RRs of 1.12 (95 % CI: 1.06–1.20) and 1.14 (95 % CI: 1.07–1.21) for contralateral breast and breast second primary cancers, respectively. The summary RR for endometrial second primary cancers was 1.46 (95 % CI: 1.17–1.83) for a 5-unit increment. This result emphasizes the importance of prevention policies aiming to reduce overweight and obesity prevalence. Clinical trials in breast cancer patients with excess body weight evaluating the effect of normal weight restoration on second primary cancer incidence are needed.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-012-2187-1</identifier><identifier>PMID: 22864804</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biological and medical sciences ; Body mass ; Body Mass Index ; Body weight ; Breast cancer ; Cancer ; Cancer research ; Cancer therapies ; Case-Control Studies ; Clinical trials ; Cohort Studies ; Dose-response effects ; Female ; Gynecology. Andrology. Obstetrics ; Health aspects ; Humans ; Life Sciences ; Mammary gland diseases ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic diseases ; Neoplasms, Second Primary - etiology ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Oncology ; Oncology, Experimental ; Overweight - complications ; Prevention ; Prospective Studies ; Review ; Reviews ; Risk ; Risk factors ; Systematic review ; Tumors</subject><ispartof>Breast cancer research and treatment, 2012-10, Vol.135 (3), p.647-654</ispartof><rights>Springer Science+Business Media, LLC. 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Springer</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-16489fe5bf291ffe0d07e94a147ab05d3f820d35037061ccbd9d0ce3d034dde73</citedby><cites>FETCH-LOGICAL-c633t-16489fe5bf291ffe0d07e94a147ab05d3f820d35037061ccbd9d0ce3d034dde73</cites><orcidid>0000-0002-3168-1350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-012-2187-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-012-2187-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26346071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22864804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02651702$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Druesne-Pecollo, Nathalie</creatorcontrib><creatorcontrib>Touvier, Mathilde</creatorcontrib><creatorcontrib>Barrandon, Emilie</creatorcontrib><creatorcontrib>Chan, Doris S. M.</creatorcontrib><creatorcontrib>Norat, Teresa</creatorcontrib><creatorcontrib>Zelek, Laurent</creatorcontrib><creatorcontrib>Hercberg, Serge</creatorcontrib><creatorcontrib>Latino-Martel, Paule</creatorcontrib><title>Excess body weight and second primary cancer risk after breast cancer: a systematic review and meta-analysis of prospective studies</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Several observational studies have investigated the role of body mass index (BMI) in second primary cancer incidence in women with breast cancer. We conducted a systematic review and meta-analysis of the evidence to assess the strength of this association. PubMed and Embase were searched for observational studies up to May 2012, and the reference lists of studies included in the analysis were examined. Random effects models were used to estimate summary relative risks (RRs) and 95 % confidence intervals (CIs). Thirteen prospective studies, five cohort and eight nested case–control studies, were included. In categorical meta-analyses of BMI, obesity was associated to significantly increased risks of contralateral breast (RR = 1.37, 95 % CI: 1.20–1.57), breast (RR = 1.40, 95 % CI: 1.24–1.58), endometrial (RR = 1.96, 95 % CI: 1.43–2.70), and colorectal (RR = 1.89, 95 % CI: 1.28–2.79) second primary cancers. For a BMI increase of 5 kg/m
2
, dose–response meta-analyses resulted in significantly increased RRs of 1.12 (95 % CI: 1.06–1.20) and 1.14 (95 % CI: 1.07–1.21) for contralateral breast and breast second primary cancers, respectively. The summary RR for endometrial second primary cancers was 1.46 (95 % CI: 1.17–1.83) for a 5-unit increment. This result emphasizes the importance of prevention policies aiming to reduce overweight and obesity prevalence. Clinical trials in breast cancer patients with excess body weight evaluating the effect of normal weight restoration on second primary cancer incidence are needed.</description><subject>Biological and medical sciences</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Case-Control Studies</subject><subject>Clinical trials</subject><subject>Cohort Studies</subject><subject>Dose-response effects</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic diseases</subject><subject>Neoplasms, Second Primary - etiology</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Overweight - complications</subject><subject>Prevention</subject><subject>Prospective Studies</subject><subject>Review</subject><subject>Reviews</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Systematic review</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk1v1DAQhiMEokvhB3BBlhAIDinjOIkTbquqUKSVuMDZcuzxrks-SsbZsmf-OE536QcCCflga_zM6_HMmyTPOZxwAPmOOBR5nQLP0oxXMuUPkgUvpEhlxuXDZAG8lGlZQXmUPCG6AIBaQv04OcqyqswryBfJz7MfBolYM9gdu0K_3gSme8sIzRC3y9F3etwxo3uDIxs9fWPahXhsRtQUDhfvmWa0o4CdDt6wEbcer651Ogw61b1ud-SJDS4qDnSJJvgtMgqT9UhPk0dOt4TPDvtx8vXD2ZfT83T1-eOn0-UqNaUQIeWx5Nph0bis5s4hWJBY55rnUjdQWOGqDKwoQEgouTGNrS0YFBZEbi1KcZy83etudKsOP1OD9up8uVJzDLKy4BKyLY_smz0b6_0-IQXVeTLYtrrHYSLFoRZ5wfNM_AcqrtmiiujLP9CLYRpjd_ZUHKQs61tqrVtUvndDGLWZRdVSFGWeyyqbtU7-QsVlsfNxeOh8jN9LeH0nYYO6DRsa2in4oaf7IN-DJs6KRnQ3zeKgZuOpvfFUrFfNxlNzv14cfjY1HdqbjN9Oi8CrA6DJ6NaN0TiebrlS5CXIWSjbcxSv-jWOd1v0r9d_AcpM7VU</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Druesne-Pecollo, Nathalie</creator><creator>Touvier, Mathilde</creator><creator>Barrandon, Emilie</creator><creator>Chan, Doris S. 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M.</au><au>Norat, Teresa</au><au>Zelek, Laurent</au><au>Hercberg, Serge</au><au>Latino-Martel, Paule</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excess body weight and second primary cancer risk after breast cancer: a systematic review and meta-analysis of prospective studies</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>135</volume><issue>3</issue><spage>647</spage><epage>654</epage><pages>647-654</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>Several observational studies have investigated the role of body mass index (BMI) in second primary cancer incidence in women with breast cancer. We conducted a systematic review and meta-analysis of the evidence to assess the strength of this association. PubMed and Embase were searched for observational studies up to May 2012, and the reference lists of studies included in the analysis were examined. Random effects models were used to estimate summary relative risks (RRs) and 95 % confidence intervals (CIs). Thirteen prospective studies, five cohort and eight nested case–control studies, were included. In categorical meta-analyses of BMI, obesity was associated to significantly increased risks of contralateral breast (RR = 1.37, 95 % CI: 1.20–1.57), breast (RR = 1.40, 95 % CI: 1.24–1.58), endometrial (RR = 1.96, 95 % CI: 1.43–2.70), and colorectal (RR = 1.89, 95 % CI: 1.28–2.79) second primary cancers. For a BMI increase of 5 kg/m
2
, dose–response meta-analyses resulted in significantly increased RRs of 1.12 (95 % CI: 1.06–1.20) and 1.14 (95 % CI: 1.07–1.21) for contralateral breast and breast second primary cancers, respectively. The summary RR for endometrial second primary cancers was 1.46 (95 % CI: 1.17–1.83) for a 5-unit increment. This result emphasizes the importance of prevention policies aiming to reduce overweight and obesity prevalence. Clinical trials in breast cancer patients with excess body weight evaluating the effect of normal weight restoration on second primary cancer incidence are needed.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22864804</pmid><doi>10.1007/s10549-012-2187-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3168-1350</orcidid></addata></record> |
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| ispartof | Breast cancer research and treatment, 2012-10, Vol.135 (3), p.647-654 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biological and medical sciences Body mass Body Mass Index Body weight Breast cancer Cancer Cancer research Cancer therapies Case-Control Studies Clinical trials Cohort Studies Dose-response effects Female Gynecology. Andrology. Obstetrics Health aspects Humans Life Sciences Mammary gland diseases Medical sciences Medicine Medicine & Public Health Metabolic diseases Neoplasms, Second Primary - etiology Obesity Obesity - complications Obesity - epidemiology Oncology Oncology, Experimental Overweight - complications Prevention Prospective Studies Review Reviews Risk Risk factors Systematic review Tumors |
| title | Excess body weight and second primary cancer risk after breast cancer: a systematic review and meta-analysis of prospective studies |
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