Trypomastigotes and amastigotes of Trypanosoma cruzi induce apoptosis and STAT3 activation in cardiomyocytes in vitro

The haemoflagellate Trypanosoma cruzi is the causative agent of Chagas’ disease that occurs in approximately 8 million people in Latin America. Patients infected with T. cruzi frequently suffer of cardiomegaly and may die of myocardial failure. Here we show that T. cruzi trypomastigotes (extracellul...

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Veröffentlicht in:	Apoptosis (London) 2013-06, Vol.18 (6), p.653-663
Hauptverfasser:	Stahl, Philipp, Ruppert, Volker, Meyer, Thomas, Schmidt, Jörg, Campos, Marco A., Gazzinelli, Ricardo T., Maisch, Bernhard, Schwarz, Ralph T., Debierre-Grockiego, Françoise
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology bcl-2-Associated X Protein - biosynthesis Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Chagas Cardiomyopathy - physiopathology Glycosylphosphatidylinositols - pharmacology Host-Parasite Interactions Life Sciences Microbiology and Parasitology Myocytes, Cardiac - parasitology Oncology Original Paper Parasites Rats STAT3 Transcription Factor - biosynthesis STAT3 Transcription Factor - metabolism Toll-Like Receptor 7 - biosynthesis Trypanosoma cruzi Trypanosoma cruzi - physiology Up-Regulation Virology
Online-Zugang:	Volltext
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