Bacitracin and nisin resistance in Staphylococcus aureus: a novel pathway involving the BraS/BraR two‐component system (SA2417/SA2418) and both the BraD/BraE and VraD/VraE ABC transporters

Summary Two‐component systems (TCSs) are key regulatory pathways allowing bacteria to adapt their genetic expression to environmental changes. Bacitracin, a cyclic dodecylpeptide antibiotic, binds to undecaprenyl pyrophosphate, the lipid carrier for cell wall precursors, effectively inhibiting pepti...

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Veröffentlicht in:	Molecular microbiology 2011-08, Vol.81 (3), p.602-622
Hauptverfasser:	Hiron, Aurélia, Falord, Mélanie, Valle, Jaione, Débarbouillé, Michel, Msadek, Tarek
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Adaptation, Physiological Amino Acid Sequence Antibiotics Antimicrobial Cationic Peptides - metabolism ATP-Binding Cassette Transporters - metabolism Bacitracin - metabolism Bacitracin - pharmacology Bacteriology Base Sequence Biological and medical sciences Drug resistance Drug Resistance, Bacterial Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Humans Life Sciences Microbial Sensitivity Tests Microbiology Microbiology and Parasitology Miscellaneous Models, Biological Molecular Sequence Data Multigene Family Nisin - metabolism Nisin - pharmacology Operon Promoter Regions, Genetic Sequence Alignment Signal Transduction Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Staphylococcus aureus - metabolism Staphylococcus infections
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