Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice

PI3Kγ is important to drive the fibrotic processes by regulation of pulmonary inflammation and angiogenesis in mice, suggesting PI3Kγ as therapeutic target for pulmonary fibrosis. PI3Kγ is central in signaling diverse arrays of cellular functions and inflammation. Pulmonary fibrosis is associated wi...

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Veröffentlicht in:	Journal of leukocyte biology 2011-02, Vol.89 (2), p.269-282
Hauptverfasser:	Russo, Remo C., Garcia, Cristiana C., Barcelos, Lucíola S., Rachid, Milene A., Guabiraba, Rodrigo, Roffê, Ester, Souza, Adriano L. S., Sousa, Lirlândia P., Mirolo, Massimiliano, Doni, Andrea, Cassali, Geovanni D., Pinho, Vanessa, Locati, Massimo, Teixeira, Mauro M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin - toxicity Cells, Cultured chemokine Class Ib Phosphatidylinositol 3-Kinase - deficiency Class Ib Phosphatidylinositol 3-Kinase - genetics Class Ib Phosphatidylinositol 3-Kinase - physiology Disease Models, Animal Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Human health and pathology Humans Immunology Life Sciences Lung - blood supply Lung - immunology lung angiogenesis Male Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Physiologic - immunology PI3Kγ Pneumonia - chemically induced Pneumonia - enzymology Pneumonia - pathology Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - enzymology Pulmonary Fibrosis - pathology
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