In vitro and in vivo characterization of molecular determinants of virulence in reassortant betanodavirus

We previously reported that betanodavirus reassortant strains [redspotted grouper nervous necrosis virus/striped jack nervous necrosis virus (SJNNV)] isolated from Senegalese sole (Solea senegalensis) exhibited a modified SJNNV capsid amino acid sequence, with changes at aa 247 and 270. In the curre...

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Veröffentlicht in:	Journal of general virology 2015-06, Vol.96 (Pt 6), p.1287-1296
Hauptverfasser:	Souto, Sandra, Mérour, Emilie, Biacchesi, Stéphane, Brémont, Michel, Olveira, José G, Bandín, Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Capsid Proteins - genetics Capsid Proteins - metabolism Cell Line Fish Diseases - pathology Fish Diseases - virology Flatfishes - virology Life Sciences Mutation, Missense Nodaviridae - genetics Nodaviridae - growth & development Nodaviridae - pathogenicity Nodaviridae - physiology Point Mutation Reassortant Viruses - genetics Reassortant Viruses - growth & development Reassortant Viruses - pathogenicity Reassortant Viruses - physiology Reverse Genetics RNA Virus Infections - pathology RNA Virus Infections - veterinary RNA Virus Infections - virology Survival Analysis Viral Load Virulence Virulence Factors - genetics Virulence Factors - metabolism Virus Replication
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