Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility?
The aim of this study was to investigate in a case-control study the associations between idiopathic infertility and antioxidant gene polymorphisms. One hundred ten infertile subjects (58 women and 52 men) with a history of idiopathic infertility and 69 fertile subjects (35 women and 34 men) with no...
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| Veröffentlicht in: | Antioxidants & redox signaling 2014-08, Vol.21 (4), p.565-569 |
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| creator | Faure, Celine Leveille, Pauline Dupont, Charlotte Julia, Chantal Chavatte-Palmer, Pascale Sutton, Angela Levy, Rachel |
| description | The aim of this study was to investigate in a case-control study the associations between idiopathic infertility and antioxidant gene polymorphisms. One hundred ten infertile subjects (58 women and 52 men) with a history of idiopathic infertility and 69 fertile subjects (35 women and 34 men) with no history of infertility were included by three hospital departments of reproductive biology in the NCT01093378 French government clinical trial. Genotyping was assessed by real-time polymerase chain reaction with TaqMan assay. We examined genetic polymorphisms affecting five antioxidant enzymes: manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), glutathione peroxidase 1 (GPx1), catalase (CAT), and endothelial nitric oxide synthase (eNOS). The presence of at least 1 Ala-MnSOD allele (rs4880) increased significantly the risk of infertility (odds ratio [OR] 2.94; 95% confidence interval [CI], 1.14, 7.60; p=0.03) in male subjects. Moreover, the presence of 2 G-eNOS allele (rs1799983) increased significantly the risk of infertility in both men and women (OR 1.91; 95% CI, 1.04, 3.54; p=0.04). Our observations lead to the hypothesis that the genetic susceptibility modulating oxidative stress may represent a risk factor for male idiopathic infertility. |
| doi_str_mv | 10.1089/ars.2014.5831 |
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One hundred ten infertile subjects (58 women and 52 men) with a history of idiopathic infertility and 69 fertile subjects (35 women and 34 men) with no history of infertility were included by three hospital departments of reproductive biology in the NCT01093378 French government clinical trial. Genotyping was assessed by real-time polymerase chain reaction with TaqMan assay. We examined genetic polymorphisms affecting five antioxidant enzymes: manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), glutathione peroxidase 1 (GPx1), catalase (CAT), and endothelial nitric oxide synthase (eNOS). The presence of at least 1 Ala-MnSOD allele (rs4880) increased significantly the risk of infertility (odds ratio [OR] 2.94; 95% confidence interval [CI], 1.14, 7.60; p=0.03) in male subjects. Moreover, the presence of 2 G-eNOS allele (rs1799983) increased significantly the risk of infertility in both men and women (OR 1.91; 95% CI, 1.04, 3.54; p=0.04). Our observations lead to the hypothesis that the genetic susceptibility modulating oxidative stress may represent a risk factor for male idiopathic infertility.</description><identifier>ISSN: 1523-0864</identifier><identifier>EISSN: 1557-7716</identifier><identifier>DOI: 10.1089/ars.2014.5831</identifier><identifier>PMID: 24444339</identifier><language>eng</language><publisher>United States: Mary Ann Liebert</publisher><subject>Adult ; Catalase - genetics ; Development Biology ; Female ; Genetic Predisposition to Disease ; Glutathione Peroxidase - genetics ; Glutathione Peroxidase GPX1 ; Humans ; Infertility - genetics ; Life Sciences ; Male ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type III - genetics ; Odds Ratio ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Reproductive Biology ; Risk Factors ; Superoxide Dismutase - genetics</subject><ispartof>Antioxidants & redox signaling, 2014-08, Vol.21 (4), p.565-569</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-9a8fa22320063002ce4feaef1ae74cf112aa87155cf2cb9e0660dbe886ab17553</citedby><cites>FETCH-LOGICAL-c327t-9a8fa22320063002ce4feaef1ae74cf112aa87155cf2cb9e0660dbe886ab17553</cites><orcidid>0000-0002-7044-6935 ; 0000-0002-3168-1350 ; 0000-0002-4581-6092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24444339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02638153$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Faure, Celine</creatorcontrib><creatorcontrib>Leveille, Pauline</creatorcontrib><creatorcontrib>Dupont, Charlotte</creatorcontrib><creatorcontrib>Julia, Chantal</creatorcontrib><creatorcontrib>Chavatte-Palmer, Pascale</creatorcontrib><creatorcontrib>Sutton, Angela</creatorcontrib><creatorcontrib>Levy, Rachel</creatorcontrib><creatorcontrib>Alifert Group</creatorcontrib><creatorcontrib>Alifert Group</creatorcontrib><title>Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility?</title><title>Antioxidants & redox signaling</title><addtitle>Antioxid Redox Signal</addtitle><description>The aim of this study was to investigate in a case-control study the associations between idiopathic infertility and antioxidant gene polymorphisms. One hundred ten infertile subjects (58 women and 52 men) with a history of idiopathic infertility and 69 fertile subjects (35 women and 34 men) with no history of infertility were included by three hospital departments of reproductive biology in the NCT01093378 French government clinical trial. Genotyping was assessed by real-time polymerase chain reaction with TaqMan assay. We examined genetic polymorphisms affecting five antioxidant enzymes: manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), glutathione peroxidase 1 (GPx1), catalase (CAT), and endothelial nitric oxide synthase (eNOS). The presence of at least 1 Ala-MnSOD allele (rs4880) increased significantly the risk of infertility (odds ratio [OR] 2.94; 95% confidence interval [CI], 1.14, 7.60; p=0.03) in male subjects. Moreover, the presence of 2 G-eNOS allele (rs1799983) increased significantly the risk of infertility in both men and women (OR 1.91; 95% CI, 1.04, 3.54; p=0.04). Our observations lead to the hypothesis that the genetic susceptibility modulating oxidative stress may represent a risk factor for male idiopathic infertility.</description><subject>Adult</subject><subject>Catalase - genetics</subject><subject>Development Biology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Glutathione Peroxidase - genetics</subject><subject>Glutathione Peroxidase GPX1</subject><subject>Humans</subject><subject>Infertility - genetics</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Reproductive Biology</subject><subject>Risk Factors</subject><subject>Superoxide Dismutase - genetics</subject><issn>1523-0864</issn><issn>1557-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kTlPxDAQhS0E4lgoaZFLKLL4yFmh1YpLWokGamvWmShGSRxsB9h_j6MF3Nia-eZp_B4hl5wtOSurW3B-KRhPl1kp-QE55VlWJEXB88P5LWTCyjw9IWfevzPGBOfsmJyINB4pq1PyvnJI_TSis9-mRlob308BPFJBYajpYIIzmu6bfjeEdu6Nttv11o1tpD0F7602ELCmXya01NTGjhDaOGeGBl0wnQm7u3Ny1EDn8eL3XpC3h_vX9VOyeXl8Xq82iZaiCEkFZQNCSMFYLuPGGtMGARsOWKS64VwAlEX8pm6E3lbI8pzVWyzLHLa8yDK5IDd73RY6NTrTg9spC0Y9rTZqrjGRy5Jn8pNH9nrPjs5-TOiD6o3X2HUwoJ284ln0SYgqTixIske1s947bP61OVNzFCpGoeYo1BxF5K9-padtj_U__ee9_AHHj4X3</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Faure, Celine</creator><creator>Leveille, Pauline</creator><creator>Dupont, Charlotte</creator><creator>Julia, Chantal</creator><creator>Chavatte-Palmer, Pascale</creator><creator>Sutton, Angela</creator><creator>Levy, Rachel</creator><general>Mary Ann Liebert</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-7044-6935</orcidid><orcidid>https://orcid.org/0000-0002-3168-1350</orcidid><orcidid>https://orcid.org/0000-0002-4581-6092</orcidid></search><sort><creationdate>20140801</creationdate><title>Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility?</title><author>Faure, Celine ; Leveille, Pauline ; Dupont, Charlotte ; Julia, Chantal ; Chavatte-Palmer, Pascale ; Sutton, Angela ; Levy, Rachel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-9a8fa22320063002ce4feaef1ae74cf112aa87155cf2cb9e0660dbe886ab17553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Catalase - genetics</topic><topic>Development Biology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Glutathione Peroxidase - genetics</topic><topic>Glutathione Peroxidase GPX1</topic><topic>Humans</topic><topic>Infertility - genetics</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type III - genetics</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Reproductive Biology</topic><topic>Risk Factors</topic><topic>Superoxide Dismutase - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faure, Celine</creatorcontrib><creatorcontrib>Leveille, Pauline</creatorcontrib><creatorcontrib>Dupont, Charlotte</creatorcontrib><creatorcontrib>Julia, Chantal</creatorcontrib><creatorcontrib>Chavatte-Palmer, Pascale</creatorcontrib><creatorcontrib>Sutton, Angela</creatorcontrib><creatorcontrib>Levy, Rachel</creatorcontrib><creatorcontrib>Alifert Group</creatorcontrib><creatorcontrib>Alifert Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Antioxidants & redox signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faure, Celine</au><au>Leveille, Pauline</au><au>Dupont, Charlotte</au><au>Julia, Chantal</au><au>Chavatte-Palmer, Pascale</au><au>Sutton, Angela</au><au>Levy, Rachel</au><aucorp>Alifert Group</aucorp><aucorp>Alifert Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility?</atitle><jtitle>Antioxidants & redox signaling</jtitle><addtitle>Antioxid Redox Signal</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>21</volume><issue>4</issue><spage>565</spage><epage>569</epage><pages>565-569</pages><issn>1523-0864</issn><eissn>1557-7716</eissn><abstract>The aim of this study was to investigate in a case-control study the associations between idiopathic infertility and antioxidant gene polymorphisms. One hundred ten infertile subjects (58 women and 52 men) with a history of idiopathic infertility and 69 fertile subjects (35 women and 34 men) with no history of infertility were included by three hospital departments of reproductive biology in the NCT01093378 French government clinical trial. Genotyping was assessed by real-time polymerase chain reaction with TaqMan assay. We examined genetic polymorphisms affecting five antioxidant enzymes: manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), glutathione peroxidase 1 (GPx1), catalase (CAT), and endothelial nitric oxide synthase (eNOS). The presence of at least 1 Ala-MnSOD allele (rs4880) increased significantly the risk of infertility (odds ratio [OR] 2.94; 95% confidence interval [CI], 1.14, 7.60; p=0.03) in male subjects. Moreover, the presence of 2 G-eNOS allele (rs1799983) increased significantly the risk of infertility in both men and women (OR 1.91; 95% CI, 1.04, 3.54; p=0.04). 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| subjects | Adult Catalase - genetics Development Biology Female Genetic Predisposition to Disease Glutathione Peroxidase - genetics Glutathione Peroxidase GPX1 Humans Infertility - genetics Life Sciences Male Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III - genetics Odds Ratio Polymorphism, Genetic Polymorphism, Single Nucleotide Reproductive Biology Risk Factors Superoxide Dismutase - genetics |
| title | Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility? |
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