Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor
The as-yet unidentified E. coli metabolite colibactin induces DNA damage in eukaryotic cells and promotes tumorigenesis. Its wide distribution in pathogenic and probiotic strains has raised great interest in its structure and biosynthesis. Here we show that colibactin formation involves a rare amino...
Gespeichert in:
| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (66), p.13138-13141 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 13141 |
|---|---|
| container_issue | 66 |
| container_start_page | 13138 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 51 |
| creator | Brachmann, A O Garcie, C Wu, V Martin, P Ueoka, R Oswald, E Piel, J |
| description | The as-yet unidentified E. coli metabolite colibactin induces DNA damage in eukaryotic cells and promotes tumorigenesis. Its wide distribution in pathogenic and probiotic strains has raised great interest in its structure and biosynthesis. Here we show that colibactin formation involves a rare aminomalonyl unit used as a building block. |
| doi_str_mv | 10.1039/c5cc02718g |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02636466v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1718951494</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-bd6b178fa8b28db4d1caa9f5a0941a4bf04dd630a7dfe203b03eeabf691b955a3</originalsourceid><addsrcrecordid>eNqNkUtL5UAQhRsZ8b3xB0gvZ4Rod_px00sJ4wMuuFFwF6of0Z7ppGN3rpB_b-JV19amilMfh6IOQqeUXFDC1KURxpByRavnHXRAmeSF4NXTr2UWqlgxLvbRYc7_yFxUVHtov5RUUcHlAbJ1DF6DGX2PtY956scXl33G0NtFCPHZGwh4Id78OGHrBjevYo9nECdIDkPn-9hBiP0U8BDD9N-N3jo8JGc2Kcd0jHZbCNmdfPYj9Hj996G-Ldb3N3f11bowvCRjoa3UdFW1UOmysppbagBUK4AoToHrlnBrJSOwsq0rCdOEOQe6lYpqJQSwI_Rn6_sCoRmS7yBNTQTf3F6tm0UjpZzfI-UbndnfW3ZI8XXj8th0PhsXAvQubnJD538qQbniP0DJzDJJFtfzLWpSzDm59vsMSpolrKYWdf0R1s0Mn336bnTn7Df6lQ57B3DzkN8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1701893601</pqid></control><display><type>article</type><title>Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Brachmann, A O ; Garcie, C ; Wu, V ; Martin, P ; Ueoka, R ; Oswald, E ; Piel, J</creator><creatorcontrib>Brachmann, A O ; Garcie, C ; Wu, V ; Martin, P ; Ueoka, R ; Oswald, E ; Piel, J</creatorcontrib><description>The as-yet unidentified E. coli metabolite colibactin induces DNA damage in eukaryotic cells and promotes tumorigenesis. Its wide distribution in pathogenic and probiotic strains has raised great interest in its structure and biosynthesis. Here we show that colibactin formation involves a rare aminomalonyl unit used as a building block.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c5cc02718g</identifier><identifier>PMID: 26191546</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biological ; Biosynthesis ; Damage ; Deoxyribonucleic acid ; Escherichia coli - genetics ; Escherichia coli - metabolism ; Escherichia coli Proteins - genetics ; Escherichia coli Proteins - metabolism ; Formations ; Life Sciences ; Mutation ; Peptides - chemistry ; Peptides - metabolism ; Polyketides - chemistry ; Polyketides - metabolism ; Precursors ; Probiotics ; Strain</subject><ispartof>Chemical communications (Cambridge, England), 2015-01, Vol.51 (66), p.13138-13141</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-bd6b178fa8b28db4d1caa9f5a0941a4bf04dd630a7dfe203b03eeabf691b955a3</citedby><cites>FETCH-LOGICAL-c420t-bd6b178fa8b28db4d1caa9f5a0941a4bf04dd630a7dfe203b03eeabf691b955a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26191546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02636466$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Brachmann, A O</creatorcontrib><creatorcontrib>Garcie, C</creatorcontrib><creatorcontrib>Wu, V</creatorcontrib><creatorcontrib>Martin, P</creatorcontrib><creatorcontrib>Ueoka, R</creatorcontrib><creatorcontrib>Oswald, E</creatorcontrib><creatorcontrib>Piel, J</creatorcontrib><title>Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>The as-yet unidentified E. coli metabolite colibactin induces DNA damage in eukaryotic cells and promotes tumorigenesis. Its wide distribution in pathogenic and probiotic strains has raised great interest in its structure and biosynthesis. Here we show that colibactin formation involves a rare aminomalonyl unit used as a building block.</description><subject>Biological</subject><subject>Biosynthesis</subject><subject>Damage</subject><subject>Deoxyribonucleic acid</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli - metabolism</subject><subject>Escherichia coli Proteins - genetics</subject><subject>Escherichia coli Proteins - metabolism</subject><subject>Formations</subject><subject>Life Sciences</subject><subject>Mutation</subject><subject>Peptides - chemistry</subject><subject>Peptides - metabolism</subject><subject>Polyketides - chemistry</subject><subject>Polyketides - metabolism</subject><subject>Precursors</subject><subject>Probiotics</subject><subject>Strain</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtL5UAQhRsZ8b3xB0gvZ4Rod_px00sJ4wMuuFFwF6of0Z7ppGN3rpB_b-JV19amilMfh6IOQqeUXFDC1KURxpByRavnHXRAmeSF4NXTr2UWqlgxLvbRYc7_yFxUVHtov5RUUcHlAbJ1DF6DGX2PtY956scXl33G0NtFCPHZGwh4Id78OGHrBjevYo9nECdIDkPn-9hBiP0U8BDD9N-N3jo8JGc2Kcd0jHZbCNmdfPYj9Hj996G-Ldb3N3f11bowvCRjoa3UdFW1UOmysppbagBUK4AoToHrlnBrJSOwsq0rCdOEOQe6lYpqJQSwI_Rn6_sCoRmS7yBNTQTf3F6tm0UjpZzfI-UbndnfW3ZI8XXj8th0PhsXAvQubnJD538qQbniP0DJzDJJFtfzLWpSzDm59vsMSpolrKYWdf0R1s0Mn336bnTn7Df6lQ57B3DzkN8</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Brachmann, A O</creator><creator>Garcie, C</creator><creator>Wu, V</creator><creator>Martin, P</creator><creator>Ueoka, R</creator><creator>Oswald, E</creator><creator>Piel, J</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>1XC</scope></search><sort><creationdate>20150101</creationdate><title>Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor</title><author>Brachmann, A O ; Garcie, C ; Wu, V ; Martin, P ; Ueoka, R ; Oswald, E ; Piel, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-bd6b178fa8b28db4d1caa9f5a0941a4bf04dd630a7dfe203b03eeabf691b955a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biological</topic><topic>Biosynthesis</topic><topic>Damage</topic><topic>Deoxyribonucleic acid</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli - metabolism</topic><topic>Escherichia coli Proteins - genetics</topic><topic>Escherichia coli Proteins - metabolism</topic><topic>Formations</topic><topic>Life Sciences</topic><topic>Mutation</topic><topic>Peptides - chemistry</topic><topic>Peptides - metabolism</topic><topic>Polyketides - chemistry</topic><topic>Polyketides - metabolism</topic><topic>Precursors</topic><topic>Probiotics</topic><topic>Strain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brachmann, A O</creatorcontrib><creatorcontrib>Garcie, C</creatorcontrib><creatorcontrib>Wu, V</creatorcontrib><creatorcontrib>Martin, P</creatorcontrib><creatorcontrib>Ueoka, R</creatorcontrib><creatorcontrib>Oswald, E</creatorcontrib><creatorcontrib>Piel, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brachmann, A O</au><au>Garcie, C</au><au>Wu, V</au><au>Martin, P</au><au>Ueoka, R</au><au>Oswald, E</au><au>Piel, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>51</volume><issue>66</issue><spage>13138</spage><epage>13141</epage><pages>13138-13141</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>The as-yet unidentified E. coli metabolite colibactin induces DNA damage in eukaryotic cells and promotes tumorigenesis. Its wide distribution in pathogenic and probiotic strains has raised great interest in its structure and biosynthesis. Here we show that colibactin formation involves a rare aminomalonyl unit used as a building block.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>26191546</pmid><doi>10.1039/c5cc02718g</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2015-01, Vol.51 (66), p.13138-13141 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02636466v1 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biological Biosynthesis Damage Deoxyribonucleic acid Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Formations Life Sciences Mutation Peptides - chemistry Peptides - metabolism Polyketides - chemistry Polyketides - metabolism Precursors Probiotics Strain |
| title | Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T16%3A54%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Colibactin%20biosynthesis%20and%20biological%20activity%20depend%20on%20the%20rare%20aminomalonyl%20polyketide%20precursor&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Brachmann,%20A%20O&rft.date=2015-01-01&rft.volume=51&rft.issue=66&rft.spage=13138&rft.epage=13141&rft.pages=13138-13141&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c5cc02718g&rft_dat=%3Cproquest_hal_p%3E1718951494%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1701893601&rft_id=info:pmid/26191546&rfr_iscdi=true |