Poly(I:C)-Induced Protection of Neonatal Mice Against Intestinal Cryptosporidium parvum Infection Requires an Additional TLR5 Signal Provided by the Gut Flora

The neonatal intestinal immune system is still undergoing development at birth, leading to a higher susceptibility to mucosal infections. In this study, we investigated the effect of poly(I:C) on controlling enteric infection by the protozoan Cryptospondium parvum in neonatal mice. After poly(I:C) a...

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Veröffentlicht in:	The Journal of infectious diseases 2014-02, Vol.209 (3), p.457-467
Hauptverfasser:	Lantier, Louis, Drouet, Françoise, Guesdon, William, Mancassola, Roselyne, Metton, Coralie, Lo-Man, Richard, Werts, Catherine, Laurent, Fabrice, Lacroix-Lamandé, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Animals Animals, Newborn Biological and medical sciences Cryptosporidiosis Cryptosporidiosis - prevention & control Cryptosporidium parvum - immunology Cytokines Dendritic cells Epithelial cells Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - immunology Gastrointestinal Tract - parasitology Human protozoal diseases Infections Infectious diseases Interferons Interleukins Intestines Life Sciences Medical sciences Messenger RNA Mice Mice, Inbred C57BL Microbiology Microbiology and Parasitology Microbiota Microbiota - immunology Myeloid Differentiation Factor 88 - metabolism Parasites Parasitic diseases Poly I-C - administration & dosage Protozoal diseases Signal Transduction Toll-Like Receptor 5 - immunology
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