(E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests

The current study was aimed to assess the protective effect of a new molecule (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided...

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Veröffentlicht in:	European journal of pharmacology 2020-08, Vol.881, p.173137, Article 173137
Hauptverfasser:	Khdhiri, Emna, Mnafgui, Kais, Ghazouani, Lakhdar, Feriani, Anouar, Hajji, Raouf, Bouzanna, Walid, Allouche, Noureddine, Bazureau, Jean-Pierre, Ammar, Houcine, Abid, Souhir
Format:	Artikel
Sprache:	eng
Schlagworte:	(E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide ACE Action Potentials - drug effects Angiotensin-Converting Enzyme Inhibitors - chemical synthesis Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - pharmacology Biomarkers - blood Cardiotoxicity Chemical Sciences Disease Models, Animal Fibrinogen - metabolism Fibrinolytic Agents - chemical synthesis Fibrinolytic Agents - pharmacology Heart Rate - drug effects Hydrazones - chemical synthesis Hydrazones - pharmacology Isoproterenol Life Sciences Lipids - blood Male Myocardial infarction Myocardial Infarction - chemically induced Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Necrosis Rats, Wistar Thrombolytic Ventricular Remodeling - drug effects
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