Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet

PURPOSE: We recently reported that direct and maternal supplementation with n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) alleviates the metabolic disturbances in adult hamster pups fed with a high-fat diet (HFD). In this study, we hypothesized that these results involved a perinatal modu...

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Veröffentlicht in:	European journal of nutrition 2016-03, Vol.55 (2), p.589-599
Hauptverfasser:	Kasbi-Chadli, Fatima, Ferchaud-Roucher, Véronique, Krempf, Michel, Ouguerram, Khadija
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - metabolism adults Animals Antigens, CD - blood blood glucose Blood Glucose - metabolism ceramides Ceramides - metabolism Chemistry Chemistry and Materials Science Cholesterol, HDL - blood Cholesterol, LDL - blood Cricetinae Diacylglycerol O-Acyltransferase - genetics Diacylglycerol O-Acyltransferase - metabolism diacylglycerols Diet, High-Fat Dietary Supplements Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty Acids, Omega-3 - pharmacology fatty-acid synthase Female Food engineering gene expression glucose glucose tolerance hamsters high fat diet Hypertriglyceridemia - diet therapy Lactosylceramides - blood Life Sciences lipogenesis Lipogenesis - drug effects liver Liver - drug effects Liver - metabolism long chain polyunsaturated fatty acids Lysophospholipids - metabolism Male males Maternal Nutritional Physiological Phenomena mothers Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism muscles Nutrition Original Contribution progeny pups RNA, Messenger - genetics RNA, Messenger - metabolism secretion Sphingolipids - blood sphingosine Sphingosine - analogs & derivatives Sphingosine - metabolism stearoyl-CoA desaturase Stearoyl-CoA Desaturase - genetics Stearoyl-CoA Desaturase - metabolism Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism triacylglycerols Triglycerides - blood tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism weaning
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