Regulation of the Immune Response to α-Gal and Vector-borne Diseases
Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-gal) following a tick bite was...
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| Veröffentlicht in: | Trends in parasitology 2015-10, Vol.31 (10), p.470-476 |
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| creator | Cabezas-Cruz, Alejandro Mateos-Hernández, Lourdes Pérez-Cruz, Magdiel Valdés, James J Mera, Isabel G. Fernández de Villar, Margarita de la Fuente, José |
| description | Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-α-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of α-gal. Establishing the source of α-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases. |
| doi_str_mv | 10.1016/j.pt.2015.06.016 |
| format | Article |
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| subjects | alpha-gal Animals Arthropod Proteins - immunology Arthropod Vectors - immunology Arthropoda Disease Vectors Gastroenterology and Hepatology Host-Parasite Interactions - immunology Humans Hypersensitivity - immunology Immunoglobulin E - immunology Infectious Disease Ixodidae Life Sciences malaria Th2 Cells - immunology tick vaccine vector-borne diseases |
| title | Regulation of the Immune Response to α-Gal and Vector-borne Diseases |
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