Early life stress induces type 2 diabetes-like features in ageing mice

•Maternal separation is a risk factor for glucose intolerance in ageing mice.•Maternal separation induces microbiota dysbiosis in favor to pathobionts.•Maternal separation-induced glucose intolerance is associated with decrease of intestinal IL-17 and IL-22 responses. Early life stress is known to i...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2019-08, Vol.80, p.452-463
Hauptverfasser:	Ilchmann-Diounou, Hanna, Olier, Maïwenn, Lencina, Corinne, Riba, Ambre, Barretto, Sharon, Nankap, Michèle, Sommer, Caroline, Guillou, Hervé, Ellero-Simatos, Sandrine, Guzylack-Piriou, Laurence, Théodorou, Vassilia, Ménard, Sandrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Type 2 - complications DOHaD Dysbiosis - metabolism Female Gastrointestinal Microbiome - physiology Glucose Intolerance - etiology Glucose Intolerance - metabolism Glucose Intolerance - physiopathology Inflammation - metabolism Insulin Resistance - physiology Intestinal barrier Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestines - microbiology Life Sciences Male Maternal Deprivation Mice Mice, Inbred C3H Mice, Inbred C57BL Microbiota - physiology Microbiota dysbiosis Non-communicable diseases Obesity - metabolism Stress, Psychological - physiopathology
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