Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation

•Maternal omega-3 deficiency has deleterious effects on pups’ brain development.•Maternal omega-3 deficiency alters fatty acid composition of the fetal and adult offspring brain.•Maternal omega-3 deficiency exacerbates maternal and fetal inflammation.•Maternal omega-3 deficiency induces spatial memo...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2018-10, Vol.73, p.427-440
Hauptverfasser:	Labrousse, V.F., Leyrolle, Q., Amadieu, C., Aubert, A., Sere, A, Coutureau, E., Grégoire, S., Bretillon, L., Pallet, V., Gressens, P., Joffre, C., Nadjar, A., Layé, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Behavior, Animal - drug effects Brain - drug effects Cytokines Cytokines - drug effects Dietary Supplements Disease Models, Animal Fatty Acids, Omega-3 - deficiency Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-3 - pharmacology Fatty Acids, Omega-6 - metabolism Fatty Acids, Omega-6 - physiology Female Food and Nutrition Inflammation - metabolism Life Sciences Lipopolysaccharides - pharmacology LPS Memory Memory Disorders - metabolism Memory Disorders - physiopathology MIA Mice Mice, Inbred C57BL Microglia Microglia - drug effects Neurodevelopmental Disorders - etiology Neurodevelopmental Disorders - metabolism Neurons and Cognition Omega-3 Pregnancy Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - metabolism PUFA Social Behavior Spatial Memory - drug effects
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