Modulation of the gut microbiota to improve innate resistance
•Host and microbiota cooperate to maintain a gut ecosystem refractory to pathogen colonization.•Specific bacteria enhance protection via intermicrobial competition or by modulating host metabolism and immunity.•The gut microbiota contributes to colonization resistance at extra-intestinal sites throu...
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Veröffentlicht in: | Current opinion in immunology 2018-10, Vol.54, p.137-144 |
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container_title | Current opinion in immunology |
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creator | Schnupf, Pamela Gaboriau-Routhiau, Valérie Cerf-Bensussan, Nadine |
description | •Host and microbiota cooperate to maintain a gut ecosystem refractory to pathogen colonization.•Specific bacteria enhance protection via intermicrobial competition or by modulating host metabolism and immunity.•The gut microbiota contributes to colonization resistance at extra-intestinal sites through MAMPS and metabolites.•Diet modulates colonization resistance by influencing microbiota composition and metabolism.
One major benefit from the association of hosts with the complex microbial communities that establish at body surfaces is the resistance to pathogen infection. This protective role of symbiotic microbes is becoming ever more relevant, given the alarming rise of multidrug-resistant pathogens and severe infections in patients following extensive antibiotic treatment. Herein, we highlight some recent mechanistic studies that have provided insights into how the highly dynamic dialogue amongst intestinal bacteria and between intestinal bacteria and their host can contribute to protect the host against pathogens in and outside the gut. We then discuss how delineating the rules of this dialogue can help design strategies to modulate the microbiota and improve host resistance to infections. |
doi_str_mv | 10.1016/j.coi.2018.08.003 |
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One major benefit from the association of hosts with the complex microbial communities that establish at body surfaces is the resistance to pathogen infection. This protective role of symbiotic microbes is becoming ever more relevant, given the alarming rise of multidrug-resistant pathogens and severe infections in patients following extensive antibiotic treatment. Herein, we highlight some recent mechanistic studies that have provided insights into how the highly dynamic dialogue amongst intestinal bacteria and between intestinal bacteria and their host can contribute to protect the host against pathogens in and outside the gut. We then discuss how delineating the rules of this dialogue can help design strategies to modulate the microbiota and improve host resistance to infections.</description><identifier>ISSN: 0952-7915</identifier><identifier>EISSN: 1879-0372</identifier><identifier>DOI: 10.1016/j.coi.2018.08.003</identifier><identifier>PMID: 30205357</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Bacteria - immunology ; Gastrointestinal Microbiome - immunology ; Humans ; Immunity, Innate - immunology ; Life Sciences</subject><ispartof>Current opinion in immunology, 2018-10, Vol.54, p.137-144</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Ltd.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-6fadf5ef22ef75c8254dacddeee7103df6d893778dbaab88d18ac981bb5064b33</citedby><cites>FETCH-LOGICAL-c435t-6fadf5ef22ef75c8254dacddeee7103df6d893778dbaab88d18ac981bb5064b33</cites><orcidid>0000-0002-7662-4034 ; 0000-0003-0665-1245</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0952791518300876$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30205357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02621543$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Schnupf, Pamela</creatorcontrib><creatorcontrib>Gaboriau-Routhiau, Valérie</creatorcontrib><creatorcontrib>Cerf-Bensussan, Nadine</creatorcontrib><title>Modulation of the gut microbiota to improve innate resistance</title><title>Current opinion in immunology</title><addtitle>Curr Opin Immunol</addtitle><description>•Host and microbiota cooperate to maintain a gut ecosystem refractory to pathogen colonization.•Specific bacteria enhance protection via intermicrobial competition or by modulating host metabolism and immunity.•The gut microbiota contributes to colonization resistance at extra-intestinal sites through MAMPS and metabolites.•Diet modulates colonization resistance by influencing microbiota composition and metabolism.
One major benefit from the association of hosts with the complex microbial communities that establish at body surfaces is the resistance to pathogen infection. This protective role of symbiotic microbes is becoming ever more relevant, given the alarming rise of multidrug-resistant pathogens and severe infections in patients following extensive antibiotic treatment. Herein, we highlight some recent mechanistic studies that have provided insights into how the highly dynamic dialogue amongst intestinal bacteria and between intestinal bacteria and their host can contribute to protect the host against pathogens in and outside the gut. We then discuss how delineating the rules of this dialogue can help design strategies to modulate the microbiota and improve host resistance to infections.</description><subject>Animals</subject><subject>Bacteria - immunology</subject><subject>Gastrointestinal Microbiome - immunology</subject><subject>Humans</subject><subject>Immunity, Innate - immunology</subject><subject>Life Sciences</subject><issn>0952-7915</issn><issn>1879-0372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAUgIMoOqd_gBfpUQ-dL8nSpoiHMfwFEy96Dmnyqhlto0068L83Y-pNeBAIXz5ePkLOKMwo0OJqPTPezRhQOYM0wPfIhMqyyoGXbJ9MoBIsLysqjshxCGsAEILDITniwEBwUU7IzZO3Y6uj833mmyy-Y_Y2xqxzZvC181Fn0Weu-xj8BjPX9zpiNmBwIere4Ak5aHQb8PTnnJLXu9uX5UO-er5_XC5WuZlzEfOi0bYR2DCGTSmMZGJutbEWEUsK3DaFlRUvS2lrrWspLZXaVJLWtYBiXnM-JZc777tu1cfgOj18Ka-delis1PYOWMGomPMNTezFjk07f44YoupcMNi2ukc_BsUosIpKyaqE0h2aPhvCgM2fm4LaFlZrlQqrbWEFaWC7yvmPfqw7tH8vfpMm4HoHYAqycTioYBymWNYNaKKySfi__hvNSIt_</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Schnupf, Pamela</creator><creator>Gaboriau-Routhiau, Valérie</creator><creator>Cerf-Bensussan, Nadine</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-7662-4034</orcidid><orcidid>https://orcid.org/0000-0003-0665-1245</orcidid></search><sort><creationdate>20181001</creationdate><title>Modulation of the gut microbiota to improve innate resistance</title><author>Schnupf, Pamela ; Gaboriau-Routhiau, Valérie ; Cerf-Bensussan, Nadine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-6fadf5ef22ef75c8254dacddeee7103df6d893778dbaab88d18ac981bb5064b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Bacteria - immunology</topic><topic>Gastrointestinal Microbiome - immunology</topic><topic>Humans</topic><topic>Immunity, Innate - immunology</topic><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schnupf, Pamela</creatorcontrib><creatorcontrib>Gaboriau-Routhiau, Valérie</creatorcontrib><creatorcontrib>Cerf-Bensussan, Nadine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Current opinion in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnupf, Pamela</au><au>Gaboriau-Routhiau, Valérie</au><au>Cerf-Bensussan, Nadine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of the gut microbiota to improve innate resistance</atitle><jtitle>Current opinion in immunology</jtitle><addtitle>Curr Opin Immunol</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>54</volume><spage>137</spage><epage>144</epage><pages>137-144</pages><issn>0952-7915</issn><eissn>1879-0372</eissn><abstract>•Host and microbiota cooperate to maintain a gut ecosystem refractory to pathogen colonization.•Specific bacteria enhance protection via intermicrobial competition or by modulating host metabolism and immunity.•The gut microbiota contributes to colonization resistance at extra-intestinal sites through MAMPS and metabolites.•Diet modulates colonization resistance by influencing microbiota composition and metabolism.
One major benefit from the association of hosts with the complex microbial communities that establish at body surfaces is the resistance to pathogen infection. This protective role of symbiotic microbes is becoming ever more relevant, given the alarming rise of multidrug-resistant pathogens and severe infections in patients following extensive antibiotic treatment. Herein, we highlight some recent mechanistic studies that have provided insights into how the highly dynamic dialogue amongst intestinal bacteria and between intestinal bacteria and their host can contribute to protect the host against pathogens in and outside the gut. We then discuss how delineating the rules of this dialogue can help design strategies to modulate the microbiota and improve host resistance to infections.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30205357</pmid><doi>10.1016/j.coi.2018.08.003</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7662-4034</orcidid><orcidid>https://orcid.org/0000-0003-0665-1245</orcidid></addata></record> |
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subjects | Animals Bacteria - immunology Gastrointestinal Microbiome - immunology Humans Immunity, Innate - immunology Life Sciences |
title | Modulation of the gut microbiota to improve innate resistance |
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