Low molecular weight hydrogels derived from urea based-bolaamphiphiles as new injectable biomaterials
There is a critical need for soft materials in the field of regenerative medicine and tissue engineering. However, designing injectable hydrogel scaffolds encompassing both adequate mechanical and biological properties remains a key challenge for in vivo applications. Here we use a bottom-up approac...
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| Veröffentlicht in: | Biomaterials 2017-11, Vol.145, p.72-80 |
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| container_title | Biomaterials |
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| creator | Ramin, Michael A. Latxague, Laurent Sindhu, Kotagudda Ranganath Chassande, Olivier Barthélémy, Philippe |
| description | There is a critical need for soft materials in the field of regenerative medicine and tissue engineering. However, designing injectable hydrogel scaffolds encompassing both adequate mechanical and biological properties remains a key challenge for in vivo applications. Here we use a bottom-up approach for synthesizing supramolecular gels to generate novel biomaterial candidates. We evaluated the low molecular weight gels candidates in vivo and identified one urea-containing molecule, compound 16, that avoid foreign body reactions in mice. The self-assembly of bolaamphiphiles creates a unique hydrogel supramolecular structures featuring fast gelation kinetics, high elastic moduli, thixotropic, and thermal reversibility properties. This soft material, which inhibits recognition by macrophages and fibrous deposition, exhibits long-term stability after in vivo injection. |
| doi_str_mv | 10.1016/j.biomaterials.2017.08.034 |
| format | Article |
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However, designing injectable hydrogel scaffolds encompassing both adequate mechanical and biological properties remains a key challenge for in vivo applications. Here we use a bottom-up approach for synthesizing supramolecular gels to generate novel biomaterial candidates. We evaluated the low molecular weight gels candidates in vivo and identified one urea-containing molecule, compound 16, that avoid foreign body reactions in mice. The self-assembly of bolaamphiphiles creates a unique hydrogel supramolecular structures featuring fast gelation kinetics, high elastic moduli, thixotropic, and thermal reversibility properties. 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However, designing injectable hydrogel scaffolds encompassing both adequate mechanical and biological properties remains a key challenge for in vivo applications. Here we use a bottom-up approach for synthesizing supramolecular gels to generate novel biomaterial candidates. We evaluated the low molecular weight gels candidates in vivo and identified one urea-containing molecule, compound 16, that avoid foreign body reactions in mice. The self-assembly of bolaamphiphiles creates a unique hydrogel supramolecular structures featuring fast gelation kinetics, high elastic moduli, thixotropic, and thermal reversibility properties. 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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amides - chemistry Animals Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Bioengineering Biomaterials Bolaamphiphiles Female Furans - chemistry Furans - pharmacology Hydrogels - chemical synthesis Hydrogels - chemistry Hydrogels - pharmacology Injections Life Sciences Low molecular weight hydrogelator Mice Molecular Weight Pyridones - chemistry Pyridones - pharmacology Rheology Subcutaneous implantation Supramolecular structures Urea - chemistry |
| title | Low molecular weight hydrogels derived from urea based-bolaamphiphiles as new injectable biomaterials |
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