Increased isoprostanoid levels in brain from murine model of Krabbe disease – Relevance of isoprostanes, dihomo-isoprostanes and neuroprostanes to disease severity

Krabbe disease (KD) is a rare and devastating pediatric leukodystrophy caused by mutations in the galactocerebrosidase (GALC) gene. The disease leads to impaired myelin formation and extensive myelin damage in the brain. Oxidative stress is implicated in the pathogenesis of KD but insofar few inform...

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Veröffentlicht in:	Free radical biology & medicine 2019-08, Vol.139, p.46-54
Hauptverfasser:	Signorini, Cinzia, Cardile, Venera, Pannuzzo, Giovanna, Graziano, Adriana Carol Eleonora, Durand, Thierry, Galano, Jean-Marie, Oger, Camille, Leoncini, Silvia, Cortelazzo, Alessio, Lee, Jetty Chung-Yung, Hayek, Joussef, De Felice, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenic acid Isoprostanes Krabbe disease Leukodystrophy Life Sciences Murine models Neuroprostanes Oxidative stress
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