Novel drug delivery systems for actinides (uranium and plutonium) decontamination agents
The possibility of accidents in the nuclear industry or of nuclear terrorist attacks makes the development of new decontamination strategies crucial. Among radionuclides, actinides such as uranium and plutonium and their different isotopes are considered as the most dangerous contaminants, plutonium...
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| Veröffentlicht in: | Advanced drug delivery reviews 2015-08, Vol.90, p.40-54 |
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| creator | Fattal, Elias Tsapis, Nicolas Phan, Guillaume |
| description | The possibility of accidents in the nuclear industry or of nuclear terrorist attacks makes the development of new decontamination strategies crucial. Among radionuclides, actinides such as uranium and plutonium and their different isotopes are considered as the most dangerous contaminants, plutonium displaying mostly a radiological toxicity whereas uranium exhibits mainly a chemical toxicity. Contamination occurs through ingestion, skin or lung exposure with subsequent absorption and distribution of the radionuclides to different tissues where they induce damaging effects. Different chelating agents have been synthesized but their efficacy is limited by their low tissue specificity and high toxicity. For these reasons, several groups have developed smart delivery systems to increase the local concentration of the chelating agent or to improve its biodistribution. The aim of this review is to highlight these strategies.
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| doi_str_mv | 10.1016/j.addr.2015.06.009 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2015-08, Vol.90, p.40-54 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Actinides Animals Chelating agents Chelating Agents - administration & dosage Chelating Agents - therapeutic use Decontamination Decontamination - methods Decorporation Drug Delivery Systems Humans Life Sciences Liposomes Lung delivery Nanoemulsions Plutonium Radiation Exposure Uranium |
| title | Novel drug delivery systems for actinides (uranium and plutonium) decontamination agents |
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