Protein stability during nebulization: Mind the collection step

[Display omitted] Inhaled protein therapeutics meet a growing interest for the treatment of respiratory diseases. In liquid aerosols, proteins face stresses that may generate instabilities, such as physicochemical denaturations, aggregation and loss of activity. Monitoring protein stability is thus...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2020-07, Vol.152, p.23-34
Hauptverfasser:	Bodier-Montagutelli, Elsa, Respaud, Renaud, Perret, Gérald, Baptista, Linda, Duquenne, Philippe, Heuzé-Vourc'h, Nathalie, Vecellio, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosol collection Aerosols Aerosols - chemistry Aggregation Antibodies, Monoclonal - chemistry Life Sciences Nebulization Nebulizers and Vaporizers Particle Size Pharmaceutical sciences Protein Stability Protein therapeutics Proteins - chemistry Stability studies
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