PrPc deficiency and dasatinib protect mouse intestines against radiation injury by inhibiting of c-Src

Abstract Background & Aim Despite extensive study of the contribution of cell death and apoptosis to radiation-induced acute intestinal injury, our knowledge of the signaling mechanisms involved in epithelial barrier dysfunction remains inadequate. Because PrPc plays a key role in intestinal hom...

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Veröffentlicht in:	Radiotherapy and oncology 2016-07, Vol.120 (1), p.175-183
Hauptverfasser:	Strup-Perrot, Carine, Vozenin, Marie-Catherine, Monceau, Virginie, Pouzoulet, Frederic, Petit, Benoit, Holler, Valérie, Perrot, Sébastien, Desquibert, Loïc, Fouquet, Stéphane, Souquere, Sylvie, Pierron, Gérard, Rousset, Monique, Thenet, Sophie, Cardot, Philippe, Benderitter, Marc, Deutsch, Eric, Aigueperse, Jocelyne
Format:	Artikel
Sprache:	eng
Schlagworte:	Hematology, Oncology and Palliative Medicine Intestinal wound healing Irradiation Life Sciences Mouse model Permeability
Online-Zugang:	Volltext
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