Destabilization of the 310-Helix in Peptides Based on Cα-Tetrasubstituted α-Amino Acids by Main-Chain to Side-Chain Hydrogen Bonds

The homooligopeptide series based on O,O-isopropylidene-α-hydroxymethylserine from dimer through pentamer has been synthesized to examine the conformational preferences of this new Cα-tetrasubstituted α-amino acid characterized by concomitant C i α ↔ C i α cyclization and presence of two ether oxyge...

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Veröffentlicht in:	Journal of the American Chemical Society 1998-11, Vol.120 (45), p.11558-11566
Hauptverfasser:	Wolf, Wojciech M, Stasiak, Marcin, Leplawy, Miroslav T, Bianco, Alberto, Formaggio, Fernando, Crisma, Marco, Toniolo, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Medicinal Chemistry
Online-Zugang:	Volltext
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