Synthesis, characterization and biodistribution of a new technetium-99m complex with trimethylsilylmethylisonitrile. Comparison with 99mTc-TBI and 99mTc-MIBI
An isonitrile ligand with a silicium component was synthesized and a copper salt of this ligand was then used to form a 99mTc complex. We evaluated the physicochemical characteristics of the complex and its biodistribution in rat. The chemical properties, i.e. lipophilic affinity and charge, were co...
Gespeichert in:
| Veröffentlicht in: | Nuclear medicine and biology 1995-07, Vol.22 (5), p.585-588 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 588 |
|---|---|
| container_issue | 5 |
| container_start_page | 585 |
| container_title | Nuclear medicine and biology |
| container_volume | 22 |
| creator | Bouquillon, S. Coulais, Y. Dartiguenave, M. Tafani, J.A.M. Guiraud, R. |
| description | An isonitrile ligand with a silicium component was synthesized and a copper salt of this ligand was then used to form a
99mTc complex. We evaluated the physicochemical characteristics of the complex and its biodistribution in rat. The chemical properties, i.e. lipophilic affinity and charge, were comparable to those of other
99mTc complexes formed with similar isonitrile compounds (
99mTc-MIBI and
99mTc-TBI). In contrast, the tissue biodistribution of this new technetium complex differed markedly, as it was mainly taken up in the liver and not at all in the heart. |
| doi_str_mv | 10.1016/0969-8051(95)00001-E |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02540874v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>096980519500001E</els_id><sourcerecordid>77534528</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2677-96f8d716d69607d6677fb6db482b302e712503fd6b1921a8cdf688bf5fbf464a3</originalsourceid><addsrcrecordid>eNp9kd-O1CAYxYnRrLOrb6AJF8a4iV2BaaG9MdmdjO4kY7xwvCaUPymGlhHorrPv4rtKp5O5lBvgfD8OHxwA3mB0gxGmn1BDm6JGFf7QVNcoD1ysn4EFrhkpGorL52BxRl6Cyxh_ZYSWGF2AC1bVGFO2AH9_HIbU6WjjRyg7EYRMOtgnkawfoBgUbK1XNqZg2_GoeQMFHPQjTFp2g0527Ium6aH0_d7pP_DRpg5mvNepO7ho3cHNSxv9YHPB6Ru4yrAIkzLz2WAni93d5njlvPu2udu8Ai-McFG_Ps1X4OeX9W51X2y_f92sbreFJJSx_FpTK4apog1FTNGsmZaqtqxJu0REM0wqtDSKtrghWNRSGVrXralMa0paiuUVuJ59O-H4PjcvwoF7Yfn97ZZPGiJViWpWPuDMvp_ZffC_Rx0T722U2jkxaD9Gzli1LCtSZ7CcQRl8jEGbszNGfEqQT_HwKR7eVPyYIF_nY29P_mPba3U-dIos19-d6iJK4UwQg7TxjC0pJohMbX6eMZ3_7cHqwKO0epBa2aBl4srb__fxDw8fuHs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77534528</pqid></control><display><type>article</type><title>Synthesis, characterization and biodistribution of a new technetium-99m complex with trimethylsilylmethylisonitrile. Comparison with 99mTc-TBI and 99mTc-MIBI</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Bouquillon, S. ; Coulais, Y. ; Dartiguenave, M. ; Tafani, J.A.M. ; Guiraud, R.</creator><creatorcontrib>Bouquillon, S. ; Coulais, Y. ; Dartiguenave, M. ; Tafani, J.A.M. ; Guiraud, R.</creatorcontrib><description>An isonitrile ligand with a silicium component was synthesized and a copper salt of this ligand was then used to form a
99mTc complex. We evaluated the physicochemical characteristics of the complex and its biodistribution in rat. The chemical properties, i.e. lipophilic affinity and charge, were comparable to those of other
99mTc complexes formed with similar isonitrile compounds (
99mTc-MIBI and
99mTc-TBI). In contrast, the tissue biodistribution of this new technetium complex differed markedly, as it was mainly taken up in the liver and not at all in the heart.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/0969-8051(95)00001-E</identifier><identifier>PMID: 7581167</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Chemical Phenomena ; Chemical Sciences ; Chemistry, Physical ; Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Contrast media. Radiopharmaceuticals ; Coordination chemistry ; Isotope Labeling ; Ligands ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Nitriles - chemical synthesis ; Nitriles - chemistry ; Nitriles - pharmacokinetics ; Organotechnetium Compounds - chemical synthesis ; Organotechnetium Compounds - chemistry ; Organotechnetium Compounds - pharmacokinetics ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Spectrophotometry, Ultraviolet ; Technetium Tc 99m Sestamibi - chemistry ; Tissue Distribution</subject><ispartof>Nuclear medicine and biology, 1995-07, Vol.22 (5), p.585-588</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2677-96f8d716d69607d6677fb6db482b302e712503fd6b1921a8cdf688bf5fbf464a3</citedby><cites>FETCH-LOGICAL-c2677-96f8d716d69607d6677fb6db482b302e712503fd6b1921a8cdf688bf5fbf464a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0969-8051(95)00001-E$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3612021$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7581167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02540874$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouquillon, S.</creatorcontrib><creatorcontrib>Coulais, Y.</creatorcontrib><creatorcontrib>Dartiguenave, M.</creatorcontrib><creatorcontrib>Tafani, J.A.M.</creatorcontrib><creatorcontrib>Guiraud, R.</creatorcontrib><title>Synthesis, characterization and biodistribution of a new technetium-99m complex with trimethylsilylmethylisonitrile. Comparison with 99mTc-TBI and 99mTc-MIBI</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>An isonitrile ligand with a silicium component was synthesized and a copper salt of this ligand was then used to form a
99mTc complex. We evaluated the physicochemical characteristics of the complex and its biodistribution in rat. The chemical properties, i.e. lipophilic affinity and charge, were comparable to those of other
99mTc complexes formed with similar isonitrile compounds (
99mTc-MIBI and
99mTc-TBI). In contrast, the tissue biodistribution of this new technetium complex differed markedly, as it was mainly taken up in the liver and not at all in the heart.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemical Sciences</subject><subject>Chemistry, Physical</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chromatography, Thin Layer</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Coordination chemistry</subject><subject>Isotope Labeling</subject><subject>Ligands</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitriles - chemical synthesis</subject><subject>Nitriles - chemistry</subject><subject>Nitriles - pharmacokinetics</subject><subject>Organotechnetium Compounds - chemical synthesis</subject><subject>Organotechnetium Compounds - chemistry</subject><subject>Organotechnetium Compounds - pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Technetium Tc 99m Sestamibi - chemistry</subject><subject>Tissue Distribution</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-O1CAYxYnRrLOrb6AJF8a4iV2BaaG9MdmdjO4kY7xwvCaUPymGlhHorrPv4rtKp5O5lBvgfD8OHxwA3mB0gxGmn1BDm6JGFf7QVNcoD1ysn4EFrhkpGorL52BxRl6Cyxh_ZYSWGF2AC1bVGFO2AH9_HIbU6WjjRyg7EYRMOtgnkawfoBgUbK1XNqZg2_GoeQMFHPQjTFp2g0527Ium6aH0_d7pP_DRpg5mvNepO7ho3cHNSxv9YHPB6Ru4yrAIkzLz2WAni93d5njlvPu2udu8Ai-McFG_Ps1X4OeX9W51X2y_f92sbreFJJSx_FpTK4apog1FTNGsmZaqtqxJu0REM0wqtDSKtrghWNRSGVrXralMa0paiuUVuJ59O-H4PjcvwoF7Yfn97ZZPGiJViWpWPuDMvp_ZffC_Rx0T722U2jkxaD9Gzli1LCtSZ7CcQRl8jEGbszNGfEqQT_HwKR7eVPyYIF_nY29P_mPba3U-dIos19-d6iJK4UwQg7TxjC0pJohMbX6eMZ3_7cHqwKO0epBa2aBl4srb__fxDw8fuHs</recordid><startdate>199507</startdate><enddate>199507</enddate><creator>Bouquillon, S.</creator><creator>Coulais, Y.</creator><creator>Dartiguenave, M.</creator><creator>Tafani, J.A.M.</creator><creator>Guiraud, R.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>199507</creationdate><title>Synthesis, characterization and biodistribution of a new technetium-99m complex with trimethylsilylmethylisonitrile. Comparison with 99mTc-TBI and 99mTc-MIBI</title><author>Bouquillon, S. ; Coulais, Y. ; Dartiguenave, M. ; Tafani, J.A.M. ; Guiraud, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2677-96f8d716d69607d6677fb6db482b302e712503fd6b1921a8cdf688bf5fbf464a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemical Sciences</topic><topic>Chemistry, Physical</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Chromatography, Thin Layer</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Coordination chemistry</topic><topic>Isotope Labeling</topic><topic>Ligands</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitriles - chemical synthesis</topic><topic>Nitriles - chemistry</topic><topic>Nitriles - pharmacokinetics</topic><topic>Organotechnetium Compounds - chemical synthesis</topic><topic>Organotechnetium Compounds - chemistry</topic><topic>Organotechnetium Compounds - pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Technetium Tc 99m Sestamibi - chemistry</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouquillon, S.</creatorcontrib><creatorcontrib>Coulais, Y.</creatorcontrib><creatorcontrib>Dartiguenave, M.</creatorcontrib><creatorcontrib>Tafani, J.A.M.</creatorcontrib><creatorcontrib>Guiraud, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouquillon, S.</au><au>Coulais, Y.</au><au>Dartiguenave, M.</au><au>Tafani, J.A.M.</au><au>Guiraud, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization and biodistribution of a new technetium-99m complex with trimethylsilylmethylisonitrile. Comparison with 99mTc-TBI and 99mTc-MIBI</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>1995-07</date><risdate>1995</risdate><volume>22</volume><issue>5</issue><spage>585</spage><epage>588</epage><pages>585-588</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>An isonitrile ligand with a silicium component was synthesized and a copper salt of this ligand was then used to form a
99mTc complex. We evaluated the physicochemical characteristics of the complex and its biodistribution in rat. The chemical properties, i.e. lipophilic affinity and charge, were comparable to those of other
99mTc complexes formed with similar isonitrile compounds (
99mTc-MIBI and
99mTc-TBI). In contrast, the tissue biodistribution of this new technetium complex differed markedly, as it was mainly taken up in the liver and not at all in the heart.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>7581167</pmid><doi>10.1016/0969-8051(95)00001-E</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0969-8051 |
| ispartof | Nuclear medicine and biology, 1995-07, Vol.22 (5), p.585-588 |
| issn | 0969-8051 1872-9614 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02540874v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Chemical Phenomena Chemical Sciences Chemistry, Physical Chromatography, High Pressure Liquid Chromatography, Thin Layer Contrast media. Radiopharmaceuticals Coordination chemistry Isotope Labeling Ligands Magnetic Resonance Spectroscopy Male Medical sciences Nitriles - chemical synthesis Nitriles - chemistry Nitriles - pharmacokinetics Organotechnetium Compounds - chemical synthesis Organotechnetium Compounds - chemistry Organotechnetium Compounds - pharmacokinetics Pharmacology. Drug treatments Rats Rats, Wistar Spectrophotometry, Ultraviolet Technetium Tc 99m Sestamibi - chemistry Tissue Distribution |
| title | Synthesis, characterization and biodistribution of a new technetium-99m complex with trimethylsilylmethylisonitrile. Comparison with 99mTc-TBI and 99mTc-MIBI |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T00%3A55%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis,%20characterization%20and%20biodistribution%20of%20a%20new%20technetium-99m%20complex%20with%20trimethylsilylmethylisonitrile.%20Comparison%20with%2099mTc-TBI%20and%2099mTc-MIBI&rft.jtitle=Nuclear%20medicine%20and%20biology&rft.au=Bouquillon,%20S.&rft.date=1995-07&rft.volume=22&rft.issue=5&rft.spage=585&rft.epage=588&rft.pages=585-588&rft.issn=0969-8051&rft.eissn=1872-9614&rft_id=info:doi/10.1016/0969-8051(95)00001-E&rft_dat=%3Cproquest_hal_p%3E77534528%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77534528&rft_id=info:pmid/7581167&rft_els_id=096980519500001E&rfr_iscdi=true |