Distinctive Low-Resolution Structural Features of Dimers of Antibody–Drug Conjugates and Parent Antibody Determined by Small-Angle X‑ray Scattering

Structural features of lysine-conjugated antibody–drug conjugate (ADC) from humanized IgG1 were studied by small-angle X-ray scattering (SAXS). As the physicochemical properties of the cytotoxic drug (payload) and linker may impact the conformational and colloidal stabilities of the conjugated monoc...

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Veröffentlicht in:	Molecular pharmaceutics 2019-12, Vol.16 (12), p.4902-4912
Hauptverfasser:	Law-Hine, Didier, Rudiuk, Sergii, Bonestebe, Audrey, Ienco, Romain, Huille, Sylvain, Tribet, Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Life Sciences Pharmaceutical sciences Structural Biology
Online-Zugang:	Volltext
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