Common origin of sequential cutaneous CD30+ lymphoproliferations with nodal involvement evidenced by genome‐wide clonal evolution

Aims This study sought to clarify the molecular pathways underlying the putative evolution from lymphomatoid papulosis (LyP) to cutaneous anaplastic large‐cell lymphoma (c‐ALCL) and lymph node invasion (LNI). Methods and results We analysed nine sequential tumours from the same patient presenting wi...

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Veröffentlicht in:	Histopathology 2019-03, Vol.74 (4), p.654-662
Hauptverfasser:	Xerri, Luc, Adélaïde, José, Avenin, Morgan, Guille, Arnaud, Taix, Sebastien, Bonnet, Nathalie, Carbuccia, Nadine, Garnier, Séverine, Mescam, Lenaïg, Murati, Anne, Chaffanet, Max, Coso, Diane, Bouabdallah, Reda, Bertucci, François, Birnbaum, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplastic large-cell lymphoma CD30 antigen Cellular Biology Clonal Evolution cutaneous anaplastic large‐cell lymphoma diffuse large B‐cell lymphoma Disease Progression Evolution Genetic transformation Genomes Humans Hybridization Life Sciences Lymph Nodes Lymph Nodes - pathology Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Large-Cell, Anaplastic Lymphoma, Large-Cell, Anaplastic - genetics Lymphoma, Large-Cell, Anaplastic - pathology Lymphomatoid Papulosis Lymphomatoid Papulosis - genetics Lymphomatoid Papulosis - pathology Male Middle Aged Neoplasm Recurrence, Local Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Skin Neoplasms Skin Neoplasms - genetics Skin Neoplasms - pathology Tissue inhibitor of metalloproteinase 3 Tumor suppressor genes Tumors
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