Evidence of Ventilatory Constraints in Healthy Exercising Prepubescent Children
We assessed expiratory airflow limitation (expFL) in 18 healthy prepubescent children (6 girls and 12 boys, 10.1 ± 0.3 years old), and examined how it might modulate regulation of tidal volume (VT) during exercise. The children performed a maximal incremental exercise on a cycle ergometer, preceded...
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| Veröffentlicht in: | Pediatric pulmonology 2006-02, Vol.41 (2), p.133-140 |
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| creator | Nourry, Cédric Deruelle, Fabien Fabre, Claudine Baquet, Georges Bart, Frédéric Grosbois, Jean-Marie Berthoin, Serge Mucci, Patrick |
| description | We assessed expiratory airflow limitation (expFL) in 18 healthy prepubescent children (6 girls and 12 boys, 10.1 ± 0.3 years old), and examined how it might modulate regulation of tidal volume (VT) during exercise. The children performed a maximal incremental exercise on a cycle ergometer, preceded and followed by pulmonary function tests. Throughout exercise, breathing flow‐volume loops were plotted into the maximal flow‐volume loop (MFVL) measured at rest. End‐expiratory and end‐inspiratory lung volumes were estimated by measuring expiratory reserve volume relative to forced vital capacity (ERV/FVC), and inspiratory reserve volume relative to forced vital capacity (IRV/FVC), respectively. The expFL, expressed as a percentage of VT, was defined as the part of the tidal breath meeting the boundary of the MFVL. Ten children (FL) presented an expFL at peak exercise (range, 16–78% of VT), and the remaining 8 constituted a nonflow‐limited group (NFL). At peak exercise, FL presented a higher IRV/FVC and lower ERV/FVC (P |
| doi_str_mv | 10.1002/ppul.20332 |
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The children performed a maximal incremental exercise on a cycle ergometer, preceded and followed by pulmonary function tests. Throughout exercise, breathing flow‐volume loops were plotted into the maximal flow‐volume loop (MFVL) measured at rest. End‐expiratory and end‐inspiratory lung volumes were estimated by measuring expiratory reserve volume relative to forced vital capacity (ERV/FVC), and inspiratory reserve volume relative to forced vital capacity (IRV/FVC), respectively. The expFL, expressed as a percentage of VT, was defined as the part of the tidal breath meeting the boundary of the MFVL. Ten children (FL) presented an expFL at peak exercise (range, 16–78% of VT), and the remaining 8 constituted a nonflow‐limited group (NFL). At peak exercise, FL presented a higher IRV/FVC and lower ERV/FVC (P < 0.01) than NFL children, demonstrating two different exercise breathing patterns. These results suggest that the NFL regulated VT at high lung volume, avoiding expFL, while the FL breathed at low lung volume, leading to expFL. At peak exercise, FL presented lower values of minute ventilation (P < 0.05) and oxygen uptake (P < 0.05) than NFL. Nevertheless, oxygen arterial saturation and dyspnea were similar in the two groups. In conclusion, ventilatory constraints may occur in healthy prepubescent children and result in relative dynamic hyperinflation or expiratory flow limitation. Pediatr Pulmonol. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.20332</identifier><identifier>PMID: 16358342</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; breathing pattern ; breathing reserve ; Child ; children ; exercise ; Exercise - physiology ; Exhalation - physiology ; Female ; flow-volume loop ; Forced Expiratory Flow Rates - physiology ; Humans ; Life Sciences ; Male ; mechanical ventilatory constraints ; Medical sciences ; Pneumology ; Puberty - physiology ; Reference Values ; Rest - physiology</subject><ispartof>Pediatric pulmonology, 2006-02, Vol.41 (2), p.133-140</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><rights>(c) 2005 Wiley-Liss, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5312-f6c61ac1732b765ddedd730deb8dbea2a039910f1b9d55edfeffea4816a731593</citedby><cites>FETCH-LOGICAL-c5312-f6c61ac1732b765ddedd730deb8dbea2a039910f1b9d55edfeffea4816a731593</cites><orcidid>0000-0001-7577-0673</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.20332$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.20332$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17536679$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16358342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lille.fr/hal-02530696$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Nourry, Cédric</creatorcontrib><creatorcontrib>Deruelle, Fabien</creatorcontrib><creatorcontrib>Fabre, Claudine</creatorcontrib><creatorcontrib>Baquet, Georges</creatorcontrib><creatorcontrib>Bart, Frédéric</creatorcontrib><creatorcontrib>Grosbois, Jean-Marie</creatorcontrib><creatorcontrib>Berthoin, Serge</creatorcontrib><creatorcontrib>Mucci, Patrick</creatorcontrib><title>Evidence of Ventilatory Constraints in Healthy Exercising Prepubescent Children</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>We assessed expiratory airflow limitation (expFL) in 18 healthy prepubescent children (6 girls and 12 boys, 10.1 ± 0.3 years old), and examined how it might modulate regulation of tidal volume (VT) during exercise. The children performed a maximal incremental exercise on a cycle ergometer, preceded and followed by pulmonary function tests. Throughout exercise, breathing flow‐volume loops were plotted into the maximal flow‐volume loop (MFVL) measured at rest. End‐expiratory and end‐inspiratory lung volumes were estimated by measuring expiratory reserve volume relative to forced vital capacity (ERV/FVC), and inspiratory reserve volume relative to forced vital capacity (IRV/FVC), respectively. The expFL, expressed as a percentage of VT, was defined as the part of the tidal breath meeting the boundary of the MFVL. Ten children (FL) presented an expFL at peak exercise (range, 16–78% of VT), and the remaining 8 constituted a nonflow‐limited group (NFL). At peak exercise, FL presented a higher IRV/FVC and lower ERV/FVC (P < 0.01) than NFL children, demonstrating two different exercise breathing patterns. These results suggest that the NFL regulated VT at high lung volume, avoiding expFL, while the FL breathed at low lung volume, leading to expFL. At peak exercise, FL presented lower values of minute ventilation (P < 0.05) and oxygen uptake (P < 0.05) than NFL. Nevertheless, oxygen arterial saturation and dyspnea were similar in the two groups. In conclusion, ventilatory constraints may occur in healthy prepubescent children and result in relative dynamic hyperinflation or expiratory flow limitation. Pediatr Pulmonol. © 2005 Wiley‐Liss, Inc.</description><subject>Biological and medical sciences</subject><subject>breathing pattern</subject><subject>breathing reserve</subject><subject>Child</subject><subject>children</subject><subject>exercise</subject><subject>Exercise - physiology</subject><subject>Exhalation - physiology</subject><subject>Female</subject><subject>flow-volume loop</subject><subject>Forced Expiratory Flow Rates - physiology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>mechanical ventilatory constraints</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Puberty - physiology</subject><subject>Reference Values</subject><subject>Rest - physiology</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9vEzEQxS1ERUPhwgdAewEJpC3-E9u7xxKFhCpqc6BE4mJ512NicHa39m5pvj0Om7Y3TiPN_N6bmYfQG4LPCcb0U9cN_pxixugzNCG4LHM8LcVzNCkk57koBDtFL2P8hXGaleQFOiWC8YJN6QRdz--cgaaGrLXZd2h653Xfhn02a5vYB-2aPmauyZagfb_dZ_N7CLWLrvmZrQN0QwWxTqpstnXeBGheoROrfYTXx3qGbr7Mv82W-ep68XV2scprzgjNragF0TWRjFZScGPAGMmwgaowFWiqMUuXYkuq0nAOxoK1oKcFEVoywkt2hj6MvlvtVRfcToe9arVTy4uVOvQw5QyLUtyRxL4f2S60twPEXu1cutp73UA7RCWkwFSwaQI_jmAd2hgD2EdngtUhanWIWv2LOsFvj65DtQPzhB6zTcC7I6Bjrb0NuknJPXGSMyHk4RUycn-ch_1_Vqr1-mb1sDwfNS72cP-o0eF3-oZJrjZXC_X5x2JzuRYbVbC_3oymDw</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Nourry, Cédric</creator><creator>Deruelle, Fabien</creator><creator>Fabre, Claudine</creator><creator>Baquet, Georges</creator><creator>Bart, Frédéric</creator><creator>Grosbois, Jean-Marie</creator><creator>Berthoin, Serge</creator><creator>Mucci, Patrick</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-7577-0673</orcidid></search><sort><creationdate>200602</creationdate><title>Evidence of Ventilatory Constraints in Healthy Exercising Prepubescent Children</title><author>Nourry, Cédric ; Deruelle, Fabien ; Fabre, Claudine ; Baquet, Georges ; Bart, Frédéric ; Grosbois, Jean-Marie ; Berthoin, Serge ; Mucci, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5312-f6c61ac1732b765ddedd730deb8dbea2a039910f1b9d55edfeffea4816a731593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>breathing pattern</topic><topic>breathing reserve</topic><topic>Child</topic><topic>children</topic><topic>exercise</topic><topic>Exercise - physiology</topic><topic>Exhalation - physiology</topic><topic>Female</topic><topic>flow-volume loop</topic><topic>Forced Expiratory Flow Rates - physiology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>mechanical ventilatory constraints</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Puberty - physiology</topic><topic>Reference Values</topic><topic>Rest - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nourry, Cédric</creatorcontrib><creatorcontrib>Deruelle, Fabien</creatorcontrib><creatorcontrib>Fabre, Claudine</creatorcontrib><creatorcontrib>Baquet, Georges</creatorcontrib><creatorcontrib>Bart, Frédéric</creatorcontrib><creatorcontrib>Grosbois, Jean-Marie</creatorcontrib><creatorcontrib>Berthoin, Serge</creatorcontrib><creatorcontrib>Mucci, Patrick</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nourry, Cédric</au><au>Deruelle, Fabien</au><au>Fabre, Claudine</au><au>Baquet, Georges</au><au>Bart, Frédéric</au><au>Grosbois, Jean-Marie</au><au>Berthoin, Serge</au><au>Mucci, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of Ventilatory Constraints in Healthy Exercising Prepubescent Children</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2006-02</date><risdate>2006</risdate><volume>41</volume><issue>2</issue><spage>133</spage><epage>140</epage><pages>133-140</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>We assessed expiratory airflow limitation (expFL) in 18 healthy prepubescent children (6 girls and 12 boys, 10.1 ± 0.3 years old), and examined how it might modulate regulation of tidal volume (VT) during exercise. The children performed a maximal incremental exercise on a cycle ergometer, preceded and followed by pulmonary function tests. Throughout exercise, breathing flow‐volume loops were plotted into the maximal flow‐volume loop (MFVL) measured at rest. End‐expiratory and end‐inspiratory lung volumes were estimated by measuring expiratory reserve volume relative to forced vital capacity (ERV/FVC), and inspiratory reserve volume relative to forced vital capacity (IRV/FVC), respectively. The expFL, expressed as a percentage of VT, was defined as the part of the tidal breath meeting the boundary of the MFVL. Ten children (FL) presented an expFL at peak exercise (range, 16–78% of VT), and the remaining 8 constituted a nonflow‐limited group (NFL). At peak exercise, FL presented a higher IRV/FVC and lower ERV/FVC (P < 0.01) than NFL children, demonstrating two different exercise breathing patterns. These results suggest that the NFL regulated VT at high lung volume, avoiding expFL, while the FL breathed at low lung volume, leading to expFL. At peak exercise, FL presented lower values of minute ventilation (P < 0.05) and oxygen uptake (P < 0.05) than NFL. Nevertheless, oxygen arterial saturation and dyspnea were similar in the two groups. In conclusion, ventilatory constraints may occur in healthy prepubescent children and result in relative dynamic hyperinflation or expiratory flow limitation. Pediatr Pulmonol. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16358342</pmid><doi>10.1002/ppul.20332</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7577-0673</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences breathing pattern breathing reserve Child children exercise Exercise - physiology Exhalation - physiology Female flow-volume loop Forced Expiratory Flow Rates - physiology Humans Life Sciences Male mechanical ventilatory constraints Medical sciences Pneumology Puberty - physiology Reference Values Rest - physiology |
| title | Evidence of Ventilatory Constraints in Healthy Exercising Prepubescent Children |
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