Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine)
Surface of the implantable devices is the root cause of several complications such as infections, implant loosening and chronic inflammation. There is an urgent need for multifunctional coatings that can address these shortcomings simultaneously in a manner similar to the structures of extracellular...
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| Veröffentlicht in: | Materials Science & Engineering C 2019-11, Vol.104, p.109898-109898, Article 109898 |
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| container_title | Materials Science & Engineering C |
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| creator | Knopf-Marques, Helena Barthes, Julien Lachaal, Sarah Mutschler, Angela Muller, Céline Dufour, Florent Rabineau, Morgane Courtial, Edwin-Joffrey Bystroňová, Julie Marquette, Christophe Lavalle, Philippe Vrana, Nihal Engin |
| description | Surface of the implantable devices is the root cause of several complications such as infections, implant loosening and chronic inflammation. There is an urgent need for multifunctional coatings that can address these shortcomings simultaneously in a manner similar to the structures of extracellular matrix. Herein, we developed a coating system composed of ECM components and a naturally derived polypeptide. The interactions between the coating components create an environment that enables incorporation of an antimicrobial/angiogenic polypeptide. The film composition is based gelatin and hyaluronic acid modified with aldehyde groups (HA-Ald) that can react with poly (arginine) (PAR) through transient interactions. Nanoplasmon measurements demonstrated a significantly higher loading of PAR in films containing HA-Ald with longer retention of PAR in the structure. The presence of PAR not only provides to the film surface antimicrobial (contact-killing) properties but also increased endothelial cell-cell contacts (PECAM) and VEGFA gene expression and secretion by human vascular endothelial cells. This multifunctional coating can be easily applied to surface of implants where it can enact on several problems simultaneously. |
| doi_str_mv | 10.1016/j.msec.2019.109898 |
| format | Article |
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There is an urgent need for multifunctional coatings that can address these shortcomings simultaneously in a manner similar to the structures of extracellular matrix. Herein, we developed a coating system composed of ECM components and a naturally derived polypeptide. The interactions between the coating components create an environment that enables incorporation of an antimicrobial/angiogenic polypeptide. The film composition is based gelatin and hyaluronic acid modified with aldehyde groups (HA-Ald) that can react with poly (arginine) (PAR) through transient interactions. Nanoplasmon measurements demonstrated a significantly higher loading of PAR in films containing HA-Ald with longer retention of PAR in the structure. The presence of PAR not only provides to the film surface antimicrobial (contact-killing) properties but also increased endothelial cell-cell contacts (PECAM) and VEGFA gene expression and secretion by human vascular endothelial cells. 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There is an urgent need for multifunctional coatings that can address these shortcomings simultaneously in a manner similar to the structures of extracellular matrix. Herein, we developed a coating system composed of ECM components and a naturally derived polypeptide. The interactions between the coating components create an environment that enables incorporation of an antimicrobial/angiogenic polypeptide. The film composition is based gelatin and hyaluronic acid modified with aldehyde groups (HA-Ald) that can react with poly (arginine) (PAR) through transient interactions. Nanoplasmon measurements demonstrated a significantly higher loading of PAR in films containing HA-Ald with longer retention of PAR in the structure. The presence of PAR not only provides to the film surface antimicrobial (contact-killing) properties but also increased endothelial cell-cell contacts (PECAM) and VEGFA gene expression and secretion by human vascular endothelial cells. This multifunctional coating can be easily applied to surface of implants where it can enact on several problems simultaneously.</description><subject>Aldehydes</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial coatings</subject><subject>Arginine</subject><subject>Cattle</subject><subject>Chemical Sciences</subject><subject>Coated Materials, Biocompatible - pharmacology</subject><subject>Coatings</subject><subject>Complications</subject><subject>ECM</subject><subject>Electronic implants</subject><subject>Endothelial cells</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - metabolism</subject><subject>Gelatin</subject><subject>Gelatin - pharmacology</subject><subject>Gene expression</subject><subject>Human Umbilical Vein Endothelial Cells - drug effects</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - pharmacology</subject><subject>Implants</subject><subject>Loosening</subject><subject>Material chemistry</subject><subject>Materials science</subject><subject>Multifunctionality</subject><subject>or physical chemistry</subject><subject>Peptides - pharmacology</subject><subject>Polymers</subject><subject>Polymers - pharmacology</subject><subject>Polypeptides</subject><subject>Prostheses and Implants</subject><subject>Protective coatings</subject><subject>Secretion</subject><subject>Theoretical and</subject><subject>Transplants & implants</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEYhBtR3HH1D3iQgJdd2B7z0V-BvSyL7gojXvQc0m_ensmQTsake2Cu_nLTzLoHD54Clacqoaoo3jO6ZpQ1n_brMSGsOWUyC7KT3YtixbpWlFlhL4sVlbwrKynYRfEmpT2lTSda_rq4EKySUjZ0Vfz-NrvJDrOHyQavHTkEdxoxWiB2PDjtJwJBT9ZvE-l1QkOCJ1t0i3RDdift5hh8pjVYQ0w2HvPVEYn2hsBOW08c-u20KyH4KQbncsTyxpWOW-utx-u3xatBu4Tvns7L4ueXzz_uH8vN94ev93ebEqqGT6VpKsZhqA3HDoZeSKBNb9AMjGnJWGV0y0xbQyVr2dWM6kHXFPqmh5ZyAUJcFtfn3J126hDtqONJBW3V491GLRrlNa9Y2x5ZZq_O7CGGXzOmSY02AbpcCIY5Kc67jjJaNXVGP_6D7sMcc5WZEssQQvA2U_xMQQwpRRyef8CoWtZUe7WsqZY11XnNbPrwFD33I5pny9_5MnB7BjD3drQYVQKLHtDYiDApE-z_8v8Ay8uyDA</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Knopf-Marques, Helena</creator><creator>Barthes, Julien</creator><creator>Lachaal, Sarah</creator><creator>Mutschler, Angela</creator><creator>Muller, Céline</creator><creator>Dufour, Florent</creator><creator>Rabineau, Morgane</creator><creator>Courtial, Edwin-Joffrey</creator><creator>Bystroňová, Julie</creator><creator>Marquette, Christophe</creator><creator>Lavalle, Philippe</creator><creator>Vrana, Nihal Engin</creator><general>Elsevier B.V</general><general>Elsevier BV</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-8226-977X</orcidid><orcidid>https://orcid.org/0000-0001-8798-912X</orcidid><orcidid>https://orcid.org/0000-0002-5398-6710</orcidid><orcidid>https://orcid.org/0000-0003-2671-5576</orcidid><orcidid>https://orcid.org/0000-0002-1406-5871</orcidid><orcidid>https://orcid.org/0000-0003-3019-0696</orcidid></search><sort><creationdate>20191101</creationdate><title>Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine)</title><author>Knopf-Marques, Helena ; Barthes, Julien ; Lachaal, Sarah ; Mutschler, Angela ; Muller, Céline ; Dufour, Florent ; Rabineau, Morgane ; Courtial, Edwin-Joffrey ; Bystroňová, Julie ; Marquette, Christophe ; Lavalle, Philippe ; Vrana, Nihal Engin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-d6412cf5d2e8cfb39c06bdedf11a9114da71d75c49598510afa50cb6bc7023c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aldehydes</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial coatings</topic><topic>Arginine</topic><topic>Cattle</topic><topic>Chemical Sciences</topic><topic>Coated Materials, Biocompatible - pharmacology</topic><topic>Coatings</topic><topic>Complications</topic><topic>ECM</topic><topic>Electronic implants</topic><topic>Endothelial cells</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - metabolism</topic><topic>Gelatin</topic><topic>Gelatin - pharmacology</topic><topic>Gene expression</topic><topic>Human Umbilical Vein Endothelial Cells - drug effects</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - pharmacology</topic><topic>Implants</topic><topic>Loosening</topic><topic>Material chemistry</topic><topic>Materials science</topic><topic>Multifunctionality</topic><topic>or physical chemistry</topic><topic>Peptides - pharmacology</topic><topic>Polymers</topic><topic>Polymers - pharmacology</topic><topic>Polypeptides</topic><topic>Prostheses and Implants</topic><topic>Protective coatings</topic><topic>Secretion</topic><topic>Theoretical and</topic><topic>Transplants & implants</topic><topic>Vascular Endothelial Growth Factor A - 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| ispartof | Materials Science & Engineering C, 2019-11, Vol.104, p.109898-109898, Article 109898 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aldehydes Angiogenesis Animals Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Antimicrobial coatings Arginine Cattle Chemical Sciences Coated Materials, Biocompatible - pharmacology Coatings Complications ECM Electronic implants Endothelial cells Extracellular matrix Extracellular Matrix - metabolism Gelatin Gelatin - pharmacology Gene expression Human Umbilical Vein Endothelial Cells - drug effects Humans Hyaluronic acid Hyaluronic Acid - pharmacology Implants Loosening Material chemistry Materials science Multifunctionality or physical chemistry Peptides - pharmacology Polymers Polymers - pharmacology Polypeptides Prostheses and Implants Protective coatings Secretion Theoretical and Transplants & implants Vascular Endothelial Growth Factor A - metabolism |
| title | Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine) |
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