3-Aryl-4-methyl-2-quinolones Targeting Multiresistant Staphylococcus aureus Bacteria

The NorA efflux pump lowers intracellular fluoroquinolone concentrations by expelling antibiotics through the membrane of Staphylococcus aureus. We identified 3‐aryl‐4‐methyl‐2‐quinolin‐2‐ones as compounds able to restore the activity of the NorA substrate, ciprofloxacin, against resistant S. aureus...

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Veröffentlicht in:	ChemMedChem 2013-04, Vol.8 (4), p.652-657
Hauptverfasser:	Doléans-Jordheim, Anne, Veron, Jean-Baptiste, Fendrich, Olivier, Bergeron, Emmanuelle, Montagut-Romans, Adrien, Wong, Yung-Sing, Furdui, Bianca, Freney, Jean, Dumontet, Charles, Boumendjel, Ahcène
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - toxicity Antibacterial activity antibiotics Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Cell Line Cell Survival - drug effects Ciprofloxacin - pharmacology Drug Resistance, Multiple, Bacterial efflux pumps Humans inhibitors Life Sciences Mice Mice, Inbred BALB C Microbial Sensitivity Tests Multidrug Resistance-Associated Proteins - antagonists & inhibitors Multidrug Resistance-Associated Proteins - metabolism Quinolones - chemistry Quinolones - pharmacology Quinolones - toxicity resistance Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - metabolism
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