Fully automated radiosynthesis of [ 18 F]fluoro- C -glyco-c(RGDfC): exploiting all the abilities of the AllInOne synthesizer
Radiolabelled peptides are crucial tools for biomedical research purposes. Peptides are usually labeled with fluorine-18 via an indirect prosthetic group approach, which requires a complex multistep procedure not easily automatable. However, automation is a compulsory step of paramount importance to...
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| Veröffentlicht in: | Reaction chemistry & engineering 2019-12, Vol.4 (12), p.2088-2098 |
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| creator | Collet, Charlotte Vucko, Timothé Ariztia, Julen Karcher, Gilles Pellegrini-Moïse, Nadia Lamandé-Langle, Sandrine |
| description | Radiolabelled peptides are crucial tools for biomedical research purposes. Peptides are usually labeled with fluorine-18
via
an indirect prosthetic group approach, which requires a complex multistep procedure not easily automatable. However, automation is a compulsory step of paramount importance to produce radiotracers with high reliability and minimal human involvement. Herein, we describe the fully automated radiosynthesis of [
18
F]fluoro-
C
-glyco-c(RDGfC) on an AllInOne (AIO) synthesizer, exploiting for the first time all the abilities of the AIO module. The radiotracer was prepared in high radiochemical purity
via
a challenging three-step sequence in 140 minutes with a decay-corrected radiochemical yield of 3.6 ± 0.4%. Presenting a high stability and an improved hydrophilicity, [
18
F]fluoro-
C
-glyco-c(RDGfC) could become a valuable tool in PET imaging for cancer diagnosis. Furthermore, the described automated procedure is modular and could be adapted to other prosthetic groups and/or peptides with minimal changes to afford a large panel of
18
F-radiolabeled peptides. |
| doi_str_mv | 10.1039/C9RE00303G |
| format | Article |
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via
an indirect prosthetic group approach, which requires a complex multistep procedure not easily automatable. However, automation is a compulsory step of paramount importance to produce radiotracers with high reliability and minimal human involvement. Herein, we describe the fully automated radiosynthesis of [
18
F]fluoro-
C
-glyco-c(RDGfC) on an AllInOne (AIO) synthesizer, exploiting for the first time all the abilities of the AIO module. The radiotracer was prepared in high radiochemical purity
via
a challenging three-step sequence in 140 minutes with a decay-corrected radiochemical yield of 3.6 ± 0.4%. Presenting a high stability and an improved hydrophilicity, [
18
F]fluoro-
C
-glyco-c(RDGfC) could become a valuable tool in PET imaging for cancer diagnosis. Furthermore, the described automated procedure is modular and could be adapted to other prosthetic groups and/or peptides with minimal changes to afford a large panel of
18
F-radiolabeled peptides.</description><identifier>ISSN: 2058-9883</identifier><identifier>EISSN: 2058-9883</identifier><identifier>DOI: 10.1039/C9RE00303G</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Automation ; Chemical Sciences ; Fluorine ; Fluorine isotopes ; Peptides ; Positron emission ; Prostheses ; Radioactive tracers ; Radioactivity ; Radiochemistry ; Synthesis ; Tomography</subject><ispartof>Reaction chemistry & engineering, 2019-12, Vol.4 (12), p.2088-2098</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-60b9928d65aa834bdb8d857bfe92c755647e7e7ffc9be9ba710b31ed370eab7c3</citedby><cites>FETCH-LOGICAL-c329t-60b9928d65aa834bdb8d857bfe92c755647e7e7ffc9be9ba710b31ed370eab7c3</cites><orcidid>0000-0001-8569-5793 ; 0000-0001-5576-3011</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://hal.univ-lorraine.fr/hal-02520555$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Collet, Charlotte</creatorcontrib><creatorcontrib>Vucko, Timothé</creatorcontrib><creatorcontrib>Ariztia, Julen</creatorcontrib><creatorcontrib>Karcher, Gilles</creatorcontrib><creatorcontrib>Pellegrini-Moïse, Nadia</creatorcontrib><creatorcontrib>Lamandé-Langle, Sandrine</creatorcontrib><title>Fully automated radiosynthesis of [ 18 F]fluoro- C -glyco-c(RGDfC): exploiting all the abilities of the AllInOne synthesizer</title><title>Reaction chemistry & engineering</title><description>Radiolabelled peptides are crucial tools for biomedical research purposes. Peptides are usually labeled with fluorine-18
via
an indirect prosthetic group approach, which requires a complex multistep procedure not easily automatable. However, automation is a compulsory step of paramount importance to produce radiotracers with high reliability and minimal human involvement. Herein, we describe the fully automated radiosynthesis of [
18
F]fluoro-
C
-glyco-c(RDGfC) on an AllInOne (AIO) synthesizer, exploiting for the first time all the abilities of the AIO module. The radiotracer was prepared in high radiochemical purity
via
a challenging three-step sequence in 140 minutes with a decay-corrected radiochemical yield of 3.6 ± 0.4%. Presenting a high stability and an improved hydrophilicity, [
18
F]fluoro-
C
-glyco-c(RDGfC) could become a valuable tool in PET imaging for cancer diagnosis. Furthermore, the described automated procedure is modular and could be adapted to other prosthetic groups and/or peptides with minimal changes to afford a large panel of
18
F-radiolabeled peptides.</description><subject>Automation</subject><subject>Chemical Sciences</subject><subject>Fluorine</subject><subject>Fluorine isotopes</subject><subject>Peptides</subject><subject>Positron emission</subject><subject>Prostheses</subject><subject>Radioactive tracers</subject><subject>Radioactivity</subject><subject>Radiochemistry</subject><subject>Synthesis</subject><subject>Tomography</subject><issn>2058-9883</issn><issn>2058-9883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpNkV1LwzAUhoMoOHQ3_oKAN06oJs3SJt6Nui8YDIZeiZSkTbaOrJlJK0788WbOL87FObw85-VwXgAuMLrBiPDbjC-GCBFExkegEyPKIs4YOf43n4Ku92uEEE4CyNIO-Bi1xuygaBu7EY0qoRNlZf2ublbKVx5aDZ8gZnD0rE1rnY1gBqOl2RU2Kq4W43ud9e6getsaWzVVvYTCGBhWoZCVCYr6ctgLA2Om9bxW8Mf7XblzcKKF8ar73c_A42j4kE2i2Xw8zQazqCAxb6IESc5jViZUCEb6spSsZDSVWvG4SClN-qkKpXXBpeJSpBhJglVJUqSETAtyBnoH35Uw-dZVG-F2uRVVPhnM8r2GYhp-ROkrDuzlgd06-9Iq3-Rr27o6nJfHBNN-kvAkDtT1gSqc9d4p_WuLUb4PI_8Lg3wCvuR7Cw</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Collet, Charlotte</creator><creator>Vucko, Timothé</creator><creator>Ariztia, Julen</creator><creator>Karcher, Gilles</creator><creator>Pellegrini-Moïse, Nadia</creator><creator>Lamandé-Langle, Sandrine</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-8569-5793</orcidid><orcidid>https://orcid.org/0000-0001-5576-3011</orcidid></search><sort><creationdate>20191201</creationdate><title>Fully automated radiosynthesis of [ 18 F]fluoro- C -glyco-c(RGDfC): exploiting all the abilities of the AllInOne synthesizer</title><author>Collet, Charlotte ; Vucko, Timothé ; Ariztia, Julen ; Karcher, Gilles ; Pellegrini-Moïse, Nadia ; Lamandé-Langle, Sandrine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-60b9928d65aa834bdb8d857bfe92c755647e7e7ffc9be9ba710b31ed370eab7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Automation</topic><topic>Chemical Sciences</topic><topic>Fluorine</topic><topic>Fluorine isotopes</topic><topic>Peptides</topic><topic>Positron emission</topic><topic>Prostheses</topic><topic>Radioactive tracers</topic><topic>Radioactivity</topic><topic>Radiochemistry</topic><topic>Synthesis</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collet, Charlotte</creatorcontrib><creatorcontrib>Vucko, Timothé</creatorcontrib><creatorcontrib>Ariztia, Julen</creatorcontrib><creatorcontrib>Karcher, Gilles</creatorcontrib><creatorcontrib>Pellegrini-Moïse, Nadia</creatorcontrib><creatorcontrib>Lamandé-Langle, Sandrine</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Reaction chemistry & engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collet, Charlotte</au><au>Vucko, Timothé</au><au>Ariztia, Julen</au><au>Karcher, Gilles</au><au>Pellegrini-Moïse, Nadia</au><au>Lamandé-Langle, Sandrine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fully automated radiosynthesis of [ 18 F]fluoro- C -glyco-c(RGDfC): exploiting all the abilities of the AllInOne synthesizer</atitle><jtitle>Reaction chemistry & engineering</jtitle><date>2019-12-01</date><risdate>2019</risdate><volume>4</volume><issue>12</issue><spage>2088</spage><epage>2098</epage><pages>2088-2098</pages><issn>2058-9883</issn><eissn>2058-9883</eissn><abstract>Radiolabelled peptides are crucial tools for biomedical research purposes. Peptides are usually labeled with fluorine-18
via
an indirect prosthetic group approach, which requires a complex multistep procedure not easily automatable. However, automation is a compulsory step of paramount importance to produce radiotracers with high reliability and minimal human involvement. Herein, we describe the fully automated radiosynthesis of [
18
F]fluoro-
C
-glyco-c(RDGfC) on an AllInOne (AIO) synthesizer, exploiting for the first time all the abilities of the AIO module. The radiotracer was prepared in high radiochemical purity
via
a challenging three-step sequence in 140 minutes with a decay-corrected radiochemical yield of 3.6 ± 0.4%. Presenting a high stability and an improved hydrophilicity, [
18
F]fluoro-
C
-glyco-c(RDGfC) could become a valuable tool in PET imaging for cancer diagnosis. Furthermore, the described automated procedure is modular and could be adapted to other prosthetic groups and/or peptides with minimal changes to afford a large panel of
18
F-radiolabeled peptides.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/C9RE00303G</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8569-5793</orcidid><orcidid>https://orcid.org/0000-0001-5576-3011</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2058-9883 |
| ispartof | Reaction chemistry & engineering, 2019-12, Vol.4 (12), p.2088-2098 |
| issn | 2058-9883 2058-9883 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02520555v1 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Automation Chemical Sciences Fluorine Fluorine isotopes Peptides Positron emission Prostheses Radioactive tracers Radioactivity Radiochemistry Synthesis Tomography |
| title | Fully automated radiosynthesis of [ 18 F]fluoro- C -glyco-c(RGDfC): exploiting all the abilities of the AllInOne synthesizer |
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