In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

Abstract Several studies have demonstrated that the blood–brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregu...

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Veröffentlicht in:	Brain research 2015-01, Vol.1594, p.15-26
Hauptverfasser:	Candela, Pietra, Saint-Pol, Julien, Kuntz, Mélanie, Boucau, Marie-Christine, Lamartiniere, Yordenca, Gosselet, Fabien, Fenart, Laurence
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism Animals BBB Biochemistry, Molecular Biology Blood-Brain Barrier - metabolism Blotting, Western Brain - metabolism Brain capillary endothelial cells Brain pericytes Cattle Coculture Techniques Endocytosis - physiology Endothelial Cells - metabolism Enzyme-Linked Immunosorbent Assay Humans Immunohistochemistry In Vitro Techniques Life Sciences LRP1 Neurology Pericytes - metabolism Rats Receptors, LDL - metabolism Reverse Transcriptase Polymerase Chain Reaction
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