Aptamer-based liposomes improve specific drug loading and release

Aptamer technology has shown much promise in cancer therapeutics for its targeting abilities. However, its potential to improve drug loading and release from nanocarriers has not been thoroughly explored. In this study, we employed drug-binding aptamers to actively load drugs into liposomes. We desi...

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Veröffentlicht in:	Journal of controlled release 2017-04, Vol.251, p.82-91
Hauptverfasser:	Plourde, Kevin, Derbali, Rabeb Mouna, Desrosiers, Arnaud, Dubath, Céline, Vallée-Bélisle, Alexis, Leblond, Jeanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Active loading Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Aptamer Aptamers, Nucleotide - chemistry Cell Survival Chemical Sciences Controlled release Doxorubicin Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Doxorubicin - chemistry Drug Compounding Drug Delivery Systems Drug Liberation Drug Stability Encapsulation efficiency Galenic pharmacology HeLa Cells Humans Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Life Sciences Liposome Liposomes - chemistry Medication Organic chemistry Pharmaceutical sciences Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry
Online-Zugang:	Volltext
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