Should posterior cerebral artery occlusions be recanalized? Insights from the Trevo Registry

Background and purpose The purpose of this study was to evaluate the safety and effectiveness of mechanical thrombectomy (MT) in patients with acute ischaemic stroke related to isolated and primary posterior cerebral artery (PCA) occlusions amongst the patients enrolled in the multicentre post‐marke...

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Veröffentlicht in:European journal of neurology 2020-05, Vol.27 (5), p.787-792
Hauptverfasser: Clarençon, F., Baronnet, F., Shotar, E., Degos, V., Rolla‐Bigliani, C., Bartolini, B., Veznedaroglu, E., Budzik, R., English, J., Baxter, B., Liebeskind, D. S., Krajina, A., Gupta, R., Miralbes, S., Lüttich, A., Nogueira, R. G., Samson, Y., Alamowitch, S., Sourour, N.‐A.
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container_end_page 792
container_issue 5
container_start_page 787
container_title European journal of neurology
container_volume 27
creator Clarençon, F.
Baronnet, F.
Shotar, E.
Degos, V.
Rolla‐Bigliani, C.
Bartolini, B.
Veznedaroglu, E.
Budzik, R.
English, J.
Baxter, B.
Liebeskind, D. S.
Krajina, A.
Gupta, R.
Miralbes, S.
Lüttich, A.
Nogueira, R. G.
Samson, Y.
Alamowitch, S.
Sourour, N.‐A.
description Background and purpose The purpose of this study was to evaluate the safety and effectiveness of mechanical thrombectomy (MT) in patients with acute ischaemic stroke related to isolated and primary posterior cerebral artery (PCA) occlusions amongst the patients enrolled in the multicentre post‐market Trevo Registry. Method Amongst the 2008 patients enrolled in the Trevo Registry with acute ischaemic stroke due to large vessel occlusion treated by MT, 22 patients (1.1%) [10 females (45.5%), mean age 66.2 ± 14.3 years (range 28–91)] had a PCA occlusion [17 P1 (77.3%) and five P2 occlusions (22.7%)]. Recanalization after the first Trevo (Stryker, Fremont, CA, USA) pass and at the end of the procedure was rated using the modified Thrombolysis in Cerebral Infarction (mTICI) score. Procedure‐related complications (i.e. groin puncture complication, perforation, symptomatic haemorrhage, embolus in a new territory) were also recorded. The modified Rankin Scale at 90 days was assessed. Results Median National Institutes of Health Stroke Scale at admission was 14 (interquartile range 8–16). Stroke aetiology was cardio‐embolic in 68.2% of cases. Half of the patients (11/22) received intravenous tissue plasminogen activator. 54.5% of the patients were treated under general anaesthesia. Reperfusion (i.e. mTICI 2b or 3) after first pass was obtained in 65% of cases. Final mTICI 2b–3 reperfusion was obtained in all cases. Only one (4.5%) procedure‐related complication was recorded (puncture site) that resolved after surgery. At 90‐day follow‐up, modified Rankin Scale 0–2 was obtained in 59% of the patients and 9.1% died within the first 3 months after MT. Conclusion Mechanical thrombectomy for PCA occlusions seems to be safe (
doi_str_mv 10.1111/ene.14154
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Insights from the Trevo Registry</title><source>Wiley Online Library</source><creator>Clarençon, F. ; Baronnet, F. ; Shotar, E. ; Degos, V. ; Rolla‐Bigliani, C. ; Bartolini, B. ; Veznedaroglu, E. ; Budzik, R. ; English, J. ; Baxter, B. ; Liebeskind, D. S. ; Krajina, A. ; Gupta, R. ; Miralbes, S. ; Lüttich, A. ; Nogueira, R. G. ; Samson, Y. ; Alamowitch, S. ; Sourour, N.‐A.</creator><creatorcontrib>Clarençon, F. ; Baronnet, F. ; Shotar, E. ; Degos, V. ; Rolla‐Bigliani, C. ; Bartolini, B. ; Veznedaroglu, E. ; Budzik, R. ; English, J. ; Baxter, B. ; Liebeskind, D. S. ; Krajina, A. ; Gupta, R. ; Miralbes, S. ; Lüttich, A. ; Nogueira, R. G. ; Samson, Y. ; Alamowitch, S. ; Sourour, N.‐A.</creatorcontrib><description>Background and purpose The purpose of this study was to evaluate the safety and effectiveness of mechanical thrombectomy (MT) in patients with acute ischaemic stroke related to isolated and primary posterior cerebral artery (PCA) occlusions amongst the patients enrolled in the multicentre post‐market Trevo Registry. Method Amongst the 2008 patients enrolled in the Trevo Registry with acute ischaemic stroke due to large vessel occlusion treated by MT, 22 patients (1.1%) [10 females (45.5%), mean age 66.2 ± 14.3 years (range 28–91)] had a PCA occlusion [17 P1 (77.3%) and five P2 occlusions (22.7%)]. Recanalization after the first Trevo (Stryker, Fremont, CA, USA) pass and at the end of the procedure was rated using the modified Thrombolysis in Cerebral Infarction (mTICI) score. Procedure‐related complications (i.e. groin puncture complication, perforation, symptomatic haemorrhage, embolus in a new territory) were also recorded. The modified Rankin Scale at 90 days was assessed. Results Median National Institutes of Health Stroke Scale at admission was 14 (interquartile range 8–16). Stroke aetiology was cardio‐embolic in 68.2% of cases. Half of the patients (11/22) received intravenous tissue plasminogen activator. 54.5% of the patients were treated under general anaesthesia. Reperfusion (i.e. mTICI 2b or 3) after first pass was obtained in 65% of cases. Final mTICI 2b–3 reperfusion was obtained in all cases. Only one (4.5%) procedure‐related complication was recorded (puncture site) that resolved after surgery. At 90‐day follow‐up, modified Rankin Scale 0–2 was obtained in 59% of the patients and 9.1% died within the first 3 months after MT. Conclusion Mechanical thrombectomy for PCA occlusions seems to be safe (&lt;5% procedure‐related complications) and effective. Larger repository datasets are needed.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.14154</identifier><identifier>PMID: 31997505</identifier><language>eng</language><publisher>England: John Wiley &amp; Sons, Inc</publisher><subject>Anesthesia ; Blood vessels ; Cardiology and cardiovascular system ; Cerebral blood flow ; Cerebral infarction ; Complications ; Embolism ; Hemorrhage ; Human health and pathology ; Infarction ; Intravenous administration ; Ischemia ; Life Sciences ; mechanical thrombectomy ; Neurons and Cognition ; Occlusion ; posterior cerebral artery ; Reperfusion ; Stroke ; Surgery ; t-Plasminogen activator ; Thrombolysis</subject><ispartof>European journal of neurology, 2020-05, Vol.27 (5), p.787-792</ispartof><rights>2020 European Academy of Neurology</rights><rights>2020 European Academy of Neurology.</rights><rights>Copyright © 2020 European Academy of Neurology</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4224-112e384ce37f7fd0c04fe3160a1e537816caa2e32eb392f047cd66271164c4133</citedby><cites>FETCH-LOGICAL-c4224-112e384ce37f7fd0c04fe3160a1e537816caa2e32eb392f047cd66271164c4133</cites><orcidid>0000-0002-6442-8239</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.14154$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.14154$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31997505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-02512399$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Clarençon, F.</creatorcontrib><creatorcontrib>Baronnet, F.</creatorcontrib><creatorcontrib>Shotar, E.</creatorcontrib><creatorcontrib>Degos, V.</creatorcontrib><creatorcontrib>Rolla‐Bigliani, C.</creatorcontrib><creatorcontrib>Bartolini, B.</creatorcontrib><creatorcontrib>Veznedaroglu, E.</creatorcontrib><creatorcontrib>Budzik, R.</creatorcontrib><creatorcontrib>English, J.</creatorcontrib><creatorcontrib>Baxter, B.</creatorcontrib><creatorcontrib>Liebeskind, D. S.</creatorcontrib><creatorcontrib>Krajina, A.</creatorcontrib><creatorcontrib>Gupta, R.</creatorcontrib><creatorcontrib>Miralbes, S.</creatorcontrib><creatorcontrib>Lüttich, A.</creatorcontrib><creatorcontrib>Nogueira, R. G.</creatorcontrib><creatorcontrib>Samson, Y.</creatorcontrib><creatorcontrib>Alamowitch, S.</creatorcontrib><creatorcontrib>Sourour, N.‐A.</creatorcontrib><title>Should posterior cerebral artery occlusions be recanalized? Insights from the Trevo Registry</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose The purpose of this study was to evaluate the safety and effectiveness of mechanical thrombectomy (MT) in patients with acute ischaemic stroke related to isolated and primary posterior cerebral artery (PCA) occlusions amongst the patients enrolled in the multicentre post‐market Trevo Registry. Method Amongst the 2008 patients enrolled in the Trevo Registry with acute ischaemic stroke due to large vessel occlusion treated by MT, 22 patients (1.1%) [10 females (45.5%), mean age 66.2 ± 14.3 years (range 28–91)] had a PCA occlusion [17 P1 (77.3%) and five P2 occlusions (22.7%)]. Recanalization after the first Trevo (Stryker, Fremont, CA, USA) pass and at the end of the procedure was rated using the modified Thrombolysis in Cerebral Infarction (mTICI) score. Procedure‐related complications (i.e. groin puncture complication, perforation, symptomatic haemorrhage, embolus in a new territory) were also recorded. The modified Rankin Scale at 90 days was assessed. Results Median National Institutes of Health Stroke Scale at admission was 14 (interquartile range 8–16). Stroke aetiology was cardio‐embolic in 68.2% of cases. Half of the patients (11/22) received intravenous tissue plasminogen activator. 54.5% of the patients were treated under general anaesthesia. Reperfusion (i.e. mTICI 2b or 3) after first pass was obtained in 65% of cases. Final mTICI 2b–3 reperfusion was obtained in all cases. Only one (4.5%) procedure‐related complication was recorded (puncture site) that resolved after surgery. At 90‐day follow‐up, modified Rankin Scale 0–2 was obtained in 59% of the patients and 9.1% died within the first 3 months after MT. Conclusion Mechanical thrombectomy for PCA occlusions seems to be safe (&lt;5% procedure‐related complications) and effective. Larger repository datasets are needed.</description><subject>Anesthesia</subject><subject>Blood vessels</subject><subject>Cardiology and cardiovascular system</subject><subject>Cerebral blood flow</subject><subject>Cerebral infarction</subject><subject>Complications</subject><subject>Embolism</subject><subject>Hemorrhage</subject><subject>Human health and pathology</subject><subject>Infarction</subject><subject>Intravenous administration</subject><subject>Ischemia</subject><subject>Life Sciences</subject><subject>mechanical thrombectomy</subject><subject>Neurons and Cognition</subject><subject>Occlusion</subject><subject>posterior cerebral artery</subject><subject>Reperfusion</subject><subject>Stroke</subject><subject>Surgery</subject><subject>t-Plasminogen activator</subject><subject>Thrombolysis</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10V1LHDEUBuBQlPrRXvQPlIA39WI0J8lMZq6KyPoBi0Jr7wohmznjRrKTNZmxrL_erKsiBXOTcHh4k_AS8g3YEeR1jD0egYRSfiK7IKu6ACFgK59FCUUJDHbIXkp3jDGuOPtMdgQ0jSpZuUv-_p6H0bd0GdKA0YVILUacReOpiXmyosFaPyYX-kRnSCNa0xvvHrH9SS_75G7nQ6JdDAs6zJHeRHwI9BfeujTE1Rey3Rmf8OvLvk_-nE1uTi-K6fX55enJtLCSc1kAcBS1tChUp7qWWSY7FFAxA1gKVUNljcmE40w0vGNS2baquAKopJX5r_vkcJM7N14vo1uYuNLBOH1xMtXrGeMlcNE0D5Dtj41dxnA_Yhr0wiWL3psew5g0F7JWTSXrKtOD_-hdGGP-_Vo1ULOSqXeX2xhSiti9vQCYXtejcz36uZ5sv78kjrMFtm_ytY8Mjjfgn_O4-jhJT64mm8gnIiuXWw</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Clarençon, F.</creator><creator>Baronnet, F.</creator><creator>Shotar, E.</creator><creator>Degos, V.</creator><creator>Rolla‐Bigliani, C.</creator><creator>Bartolini, B.</creator><creator>Veznedaroglu, E.</creator><creator>Budzik, R.</creator><creator>English, J.</creator><creator>Baxter, B.</creator><creator>Liebeskind, D. S.</creator><creator>Krajina, A.</creator><creator>Gupta, R.</creator><creator>Miralbes, S.</creator><creator>Lüttich, A.</creator><creator>Nogueira, R. G.</creator><creator>Samson, Y.</creator><creator>Alamowitch, S.</creator><creator>Sourour, N.‐A.</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-6442-8239</orcidid></search><sort><creationdate>202005</creationdate><title>Should posterior cerebral artery occlusions be recanalized? Insights from the Trevo Registry</title><author>Clarençon, F. ; Baronnet, F. ; Shotar, E. ; Degos, V. ; Rolla‐Bigliani, C. ; Bartolini, B. ; Veznedaroglu, E. ; Budzik, R. ; English, J. ; Baxter, B. ; Liebeskind, D. S. ; Krajina, A. ; Gupta, R. ; Miralbes, S. ; Lüttich, A. ; Nogueira, R. 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S.</au><au>Krajina, A.</au><au>Gupta, R.</au><au>Miralbes, S.</au><au>Lüttich, A.</au><au>Nogueira, R. G.</au><au>Samson, Y.</au><au>Alamowitch, S.</au><au>Sourour, N.‐A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Should posterior cerebral artery occlusions be recanalized? Insights from the Trevo Registry</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2020-05</date><risdate>2020</risdate><volume>27</volume><issue>5</issue><spage>787</spage><epage>792</epage><pages>787-792</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><abstract>Background and purpose The purpose of this study was to evaluate the safety and effectiveness of mechanical thrombectomy (MT) in patients with acute ischaemic stroke related to isolated and primary posterior cerebral artery (PCA) occlusions amongst the patients enrolled in the multicentre post‐market Trevo Registry. Method Amongst the 2008 patients enrolled in the Trevo Registry with acute ischaemic stroke due to large vessel occlusion treated by MT, 22 patients (1.1%) [10 females (45.5%), mean age 66.2 ± 14.3 years (range 28–91)] had a PCA occlusion [17 P1 (77.3%) and five P2 occlusions (22.7%)]. Recanalization after the first Trevo (Stryker, Fremont, CA, USA) pass and at the end of the procedure was rated using the modified Thrombolysis in Cerebral Infarction (mTICI) score. Procedure‐related complications (i.e. groin puncture complication, perforation, symptomatic haemorrhage, embolus in a new territory) were also recorded. The modified Rankin Scale at 90 days was assessed. Results Median National Institutes of Health Stroke Scale at admission was 14 (interquartile range 8–16). Stroke aetiology was cardio‐embolic in 68.2% of cases. Half of the patients (11/22) received intravenous tissue plasminogen activator. 54.5% of the patients were treated under general anaesthesia. Reperfusion (i.e. mTICI 2b or 3) after first pass was obtained in 65% of cases. Final mTICI 2b–3 reperfusion was obtained in all cases. Only one (4.5%) procedure‐related complication was recorded (puncture site) that resolved after surgery. At 90‐day follow‐up, modified Rankin Scale 0–2 was obtained in 59% of the patients and 9.1% died within the first 3 months after MT. Conclusion Mechanical thrombectomy for PCA occlusions seems to be safe (&lt;5% procedure‐related complications) and effective. Larger repository datasets are needed.</abstract><cop>England</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>31997505</pmid><doi>10.1111/ene.14154</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6442-8239</orcidid><oa>free_for_read</oa></addata></record>
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subjects Anesthesia
Blood vessels
Cardiology and cardiovascular system
Cerebral blood flow
Cerebral infarction
Complications
Embolism
Hemorrhage
Human health and pathology
Infarction
Intravenous administration
Ischemia
Life Sciences
mechanical thrombectomy
Neurons and Cognition
Occlusion
posterior cerebral artery
Reperfusion
Stroke
Surgery
t-Plasminogen activator
Thrombolysis
title Should posterior cerebral artery occlusions be recanalized? Insights from the Trevo Registry
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