Artificial microRNAs against the viral E6 protein provoke apoptosis in HPV positive cancer cells

High-risk human papillomavirus (HPV) types 16 and 18 are associated with more than 70% of cervical cancer cases. The oncoprotein E6 is multifunctional and has numerous cellular partners. The best-known activity of E6 is the polyubiquination of the pro-apoptotic tumor suppressor p53, targeting it for...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-10, Vol.465 (4), p.658-664
Hauptverfasser:	Bonetta, Anaëlle Charlotte, Mailly, Laurent, Robinet, Eric, Travé, Gilles, Masson, Murielle, Deryckere, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Animals Apoptosis - genetics Cancer therapy Cell Line Cervical cancer DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics Female Gene Knockdown Techniques Gene therapy Genetic Therapy Genetic Vectors HeLa Cells Human health and pathology Human papillomavirus Human papillomavirus 16 Human papillomavirus 16 - genetics Human papillomavirus 16 - pathogenicity Human papillomavirus 18 Human papillomavirus 18 - genetics Human papillomavirus 18 - pathogenicity Humans Life Sciences Mice Mice, Nude MicroRNAs - genetics Oncogene Proteins, Viral - antagonists & inhibitors Oncogene Proteins, Viral - genetics Papillomavirus Infections - pathology Papillomavirus Infections - therapy Papillomavirus Infections - virology Repressor Proteins - antagonists & inhibitors Repressor Proteins - genetics RNA interference Tumor Suppressor Protein p53 - metabolism Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - therapy Uterine Cervical Neoplasms - virology Xenograft Model Antitumor Assays
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