Campylobacter infection in adult patients with primary antibody deficiency

After correction for multiple comparisons, P < .016 was considered significant. Since 2004, 790 patients with PAD were included in the DEFI study, and 51 presented with Campylobacter infection (6.5%). [...]we could hypothesize that reinfection is more likely than persistent colonization, although colonization with multiple strains cannot be excluded. Characteristics No. or median Percentage or IQR Clinical features Digestive symptoms 81/87 93 Diarrhea 79 91 Chronic diarrhea 39 45 Abdominal pain 15 17 Vomiting 3 3 Fever 21/84 25 Bacteremia 24/97 25 Extraintestinal symptoms 18/83 22 Respiratory 7 8 Osteoarticular 5 6 Urinary 2 2 Cutaneous 5 6 Concomitant infection∗ 17/84 20 Comorbidity† 53/97 55 Complications Hospitalization 33/85 39 Duration, d 7 3-14 Late complications‡ 9/97 9 Current therapy at Campylobacter diagnosis Immunosuppressive drugs§ 35/88 40 Proton pump inhibitors 41/81 51 Ig replacement therapy 79/90 88 Antibiotic prophylaxis 30/84 36 Serum Ig levels, g/L n = 37 IgG 6.5 3.0-9.0 IgA 0.05 0.0-0.3 Undetectable IgA level 31 84 IgM 0.12 0.05-0.6 Undetectable IgM level 20/35 57 Campylobacter species n = 97 Campylobacter jejuni 55 57 Campylobacter coli 19 20 Other Campylobacter species 4 4 Unspecified 19 20 Table I Description of 97 Campylobacter episodes in 45 patients included in the DEFI study Characteristics Campylo pos (n = 37) Campylo neg (n = 288) P Population Female 22 (59) 172 (58) .98 Consanguinity 10 (27) 27 (10) .002∗ Age at CVID diagnosis 32 (25-44) 37 (26-50) .17 Clinical complications Infection only 10 (27) 167 (58)