APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment

Signals generated in response to extracellular stimuli at the plasma membrane are transmitted through cytoplasmic transduction cascades to the nucleus. We report the identification of a pathway directly linking the small GTPase Rab5, a key regulator of endocytosis, to signal transduction and mitogen...

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Veröffentlicht in:	Cell 2004-02, Vol.116 (3), p.445-456
Hauptverfasser:	Miaczynska, Marta, Christoforidis, Savvas, Giner, Angelika, Shevchenko, Anna, Uttenweiler-Joseph, Sandrine, Habermann, Bianca, Wilm, Matthias, Parton, Robert G, Zerial, Marino
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics Biochemistry, Molecular Biology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Compartmentation - genetics Cell Division - genetics Cell Membrane - metabolism Cell Membrane - ultrastructure Cell Nucleus - metabolism Cell Nucleus - ultrastructure Endocytosis - physiology Endosomes - metabolism Endosomes - ultrastructure Guanosine Triphosphate - metabolism HeLa Cells Histone Deacetylases - genetics Humans Life Sciences Mi-2 Nucleosome Remodeling and Deacetylase Complex Microscopy, Electron Protein Binding - genetics Protein Transport - genetics Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt rab5 GTP-Binding Proteins - genetics rab5 GTP-Binding Proteins - metabolism Signal Transduction - genetics
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