ROS and GSH-responsive S-nitrosoglutathione functionalized polymeric nanoparticles to overcome multidrug resistance in cancer

Multidrug resistance of cancer cells is one of the major obstacle for chemotherapeutic efficiency. Nitric oxide (NO) has raised the potential to overcome multidrug resistance (MDR) with low side effects. Herein, we report a reactive oxygen species (ROS) and glutathione (GSH) responsive nanoparticle...

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Veröffentlicht in:	Acta biomaterialia 2020-02, Vol.103, p.259-271
Hauptverfasser:	Wu, Wen, Chen, Min, Luo, Tingrong, Fan, Ying, Zhang, Jinqiang, Zhang, Yan, Zhang, Qianyu, Sapin-Minet, Anne, Gaucher, Caroline, Xia, Xuefeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile Biochemistry Biochemistry, Molecular Biology Biocompatibility Bioengineering Biomaterials Block copolymers Cancer Cell Behavior Cell Death - drug effects Cellular Biology Doxorubicin Doxorubicin - pharmacology Drug Liberation Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Endocytosis - drug effects Glutathione Glutathione-responsive HEK293 Cells Hep G2 Cells Humans Inhibitory Concentration 50 Life Sciences Multidrug resistance Multidrug resistance of cancer Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Neoplasms - drug therapy Neoplasms - pathology Nitric Oxide Organic chemistry Particle Size Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polymers - chemical synthesis Polymers - chemistry Proton Magnetic Resonance Spectroscopy Reaction kinetics Reactive oxygen species Reactive Oxygen Species - metabolism Reactive oxygen species-responsive S-nitrosoglutathione S-Nitrosoglutathione - pharmacology Side effects Subcellular Processes Sulfides - chemical synthesis Sulfides - chemistry
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