A single amino acid substitution (H451Y) in Leishmania calcium-dependent kinase SCAMK confers high tolerance and resistance to antimony

Abstract Background For almost a century, antimonials have remained the first-line drugs for the treatment of leishmaniasis. However, little is known about their mode of action and clinical resistance mechanisms. Objectives We have previously shown that Leishmania nicotinamidase (PNC1) is an essenti...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2019-11, Vol.74 (11), p.3231-3239
Hauptverfasser:	Vergnes, Baptiste, Gazanion, Elodie, Mariac, Cédric, Du Manoir, Miléna, Sollelis, Lauriane, Lopez-Rubio, José-Juan, Sterkers, Yvon, Bañuls, Anne-Laure
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences Microbiology and Parasitology Parasitology Pharmaceutical sciences Pharmacology
Online-Zugang:	Volltext
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