Identification of Serum Proton NMR Metabolomic Fingerprints Associated with Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis

Metabolomics depicts metabolic changes in biologic systems using a multiparametric analysis technique. This study assessed the metabolomic profiles of serum, obtained by proton nuclear magnetic resonance (NMR) spectroscopy, from cirrhotic patients with and without hepatocellular carcinoma (HCC). The...

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Veröffentlicht in:	Clinical cancer research 2012-12, Vol.18 (24), p.6714-6722
Hauptverfasser:	NAHON, Pierre, AMATHIEU, Roland, LE MOYEC, Laurence, TRIBA, Mohamed N, BOUCHEMAL, Nadia, NAULT, Jean-Charles, ZIOL, Marianne, SEROR, Olivier, DHONNEUR, Gilles, TRINCHET, Jean-Claude, BEAUGRAND, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Area Under Curve Biological and medical sciences Biomarkers, Tumor - blood Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - mortality Female Gastroenterology. Liver. Pancreas. Abdomen Humans Life Sciences Liver Cirrhosis, Alcoholic - blood Liver Cirrhosis, Alcoholic - diagnosis Liver Cirrhosis, Alcoholic - mortality Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - mortality Liver. Biliary tract. Portal circulation. Exocrine pancreas Magnetic Resonance Spectroscopy Male Medical sciences Metabolome Middle Aged Multivariate Analysis Other diseases. Semiology Pharmacology. Drug treatments Principal Component Analysis Prognosis ROC Curve Tumors
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