Mitochondrial localization and activity of P-glycoprotein in doxorubicin-resistant K562 cells

It is now well-established that P-glycoprotein 170 (P-gp), an efflux pump involved in multidrug resistance (MDR) is overexpressed at the plasma membrane of doxorubicin-resistant K562 leukemia cells. Nevertheless, several results suggested: (i) that P-gp-mediated drug efflux was not the only mechanis...

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Veröffentlicht in:	Biochemical pharmacology 2006-04, Vol.71 (8), p.1162-1174
Hauptverfasser:	Munteanu, Eliza, Verdier, Mireille, Grandjean-Forestier, Fabienne, Stenger, Christophe, Jayat-Vignoles, Chantal, Huet, Sylvie, Robert, Jacques, Ratinaud, Marie-Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Antibodies, Monoclonal ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Blotting, Western Cell Nucleus - metabolism Cellular Biology Doxorubicin Doxorubicin - pharmacology Drug Resistance, Multiple Drug Resistance, Neoplasm Flow Cytometry Humans Intracellular P-gp K562 Cells Life Sciences Medical sciences Microscopy, Confocal Mitochondria Mitochondria - metabolism Multidrug resistance P-glycoprotein Pharmacology. Drug treatments
Online-Zugang:	Volltext
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